2,3,3-trimethyl-6-phenylindole | 180003-61-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2,3,3-trimethyl-6-phenylindole
• 英文别名: 6-phenyl-2,3,3-trimethylindolenine；2,3,3-Trimethyl-6-phenyl-3H-indole
• CAS: 180003-61-6
• 化学式: C₁₇H₁₇N
• 分子量: 235.329
• InChiKey: GXIAISSARIHOAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3,3-trimethyl-6-phenylindole 在 四(三苯基膦)钯 、 胆碱 作用下， 以 乙醇 、 氯仿 、 丙酮 为溶剂， 反应 124.0h， 生成
  参考文献：
  名称：

  一种光致变色的有机场效应晶体管

  摘要：

  一种光致变色的有机场效应晶体管，包括有机半导体层，有机半导体层包含有螺吡喃结构类化合物，本发明将螺吡喃结构类化合物作为光致变色材料引入有机场效应晶体管中，在光照条件下，螺吡喃结构类化合物的结构发生改变，从而使晶体管的颜色变化，同时因为其结构发生改变，使得晶体管的迁移率也随之改变。

  公开号：

  CN114583051A
• 作为产物：
  描述：

  3-硝基联苯 在 palladium on activated charcoal 氢气 、 tin(ll) chloride 作用下， 以 水 、 溶剂黄146 为溶剂， 生成 2,3,3-trimethyl-6-phenylindole
  参考文献：
  名称：

  Lipophilic sulfophenylcarbocyanine dyes: Synthesis of a new class of fluorescent cell membrane probes

  摘要：

  Two lipophilic sulfophenylcarbocyanine dyes, 3 and 4, were synthesized as a new class of fluorescent cell membrane probes. Compared with other commonly used membrane probes, the new dyes have improved fluorescent quantum yield, retention in cell membranes and are easier to use in staining cells. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00263-6

文献信息

• Lipophilic cyanine dyes with enchanced aqueous solubilty
  申请人：Molecular Probes, Inc.

  公开号：US06004536A1

  公开（公告）日：1999-12-21

  The present invention relates to a family of cyanine dyes possessing lipophilic alkyl chains and either one or more reactive functional groups, bromo or chloro, or phenyl, sulfophenyl or polysulfophenyl substituents or combinations thereof. The dyes of the invention are useful for staining membranes in cells or isolated from cells, and are well-retained therein. Additionally, the reactive dyes of the invention are useful for preparing dye-conjugates, thereby conferring the membrane staining ability of the subject dye onto the resulting dye-conjugate.

  本发明涉及一类具有亲脂性烷基链和溴或氯或苯基、磺基苯基或多磺基苯基取代基或其组合的靛菁染料家族。本发明的染料适用于染色细胞中的膜或从细胞中分离出来的膜，并且在其中保持良好。此外，本发明的活性染料适用于制备染料共轭物，从而将所述染料的膜染色能力赋予所得染料共轭物。
• FLUORESCENT MEMBRANE INTERCALATING PROBES AND METHODS FOR THEIR USE
  申请人：Gray Brian D.

  公开号：US20090304598A1

  公开（公告）日：2009-12-10

  The invention relates to a family of dyes which fluoresce in the UV-VIS, far red and near infrared wavelengths of the spectrum and possess asymmetric lipophilic alkyl chains. The dyes of the invention are soluble in commercially available membrane staining dyes, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well-retained therein. Methods of utilizing the dyes to detect stained cells both in vivo and in vitro are also disclosed.

  本发明涉及一类荧光染料，其在紫外-可见光谱、远红外和近红外波长下发出荧光，并具有不对称的亲脂性烷基链。本发明的染料可溶于商业上可用的膜染料，可用作探针，用于快速染色亲脂性结构，例如细胞中或从细胞中分离出的膜，并且在其中保持良好。本发明还公开了利用这些染料在体内和体外检测染色细胞的方法。
• Near infrared fluorescent contrast agent and method for fluorescence imaging
  申请人：Kawakami Masayuki

  公开号：US20050226815A1

  公开（公告）日：2005-10-13

  A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 7 , and R 8 represent a C 1 -C 10 alkyl group or the like; R 3 , R 4 , R 5 , R 6 , R 9 , R 10 , R 11 , and R 12 represent a hydrogen atom, a C 1 -C 6 alkyl group, an aryl group or the like; X 1 and X 2 represent a C 1 -C 15 alkyl group or an aryl group and X 1 and X 2 in total have 0 to 4 carboxyl groups; m 1 , m 2 , and m 3 represents 0 or 1; L 1 to L 7 independently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.

  一种近红外荧光造影剂，在活体组织中具有良好的渗透性，可对肿瘤和/或血管进行特异性成像，该造影剂由式 (I) 所代表的化合物或其药学上可接受的盐组成，其中 R 1 , R 2 , R 7 和 R 8 代表一个 C 1 -C 10 烷基或类似物； R 3 , R 4 , R 5 , R 6 , R 9 , R 10 , R 11 和 R 12 代表氢原子、C 1 -C 6 烷基、芳基或类似基团； X 1 和 X 2 代表一个 C 1 -C 15 烷基或芳基，而 X 1 和 X 2 共有 0 至 4 个羧基；m 1 , m 2 和 m 3 代表 0 或 1；L 1 至 L 7 分别代表一个甲基；M 代表氢原子、金属或季铵盐；n 代表中和电荷所需的 1 至 7 的整数。
• NEAR INFRARED FLUORESCENT CONTRAST AGENT AND METHOD FOR FLUORESCENCE IMAGING
  申请人：Fuji Photo Film Co. Ltd.

  公开号：EP1480683A2

  公开（公告）日：2004-12-01
• Near Infrared Fluorescent Contrast Agent And Method For Fluorescence Imaging
  申请人：Kawakami Masayuki

  公开号：US20090041670A1

  公开（公告）日：2009-02-12

  A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 7 , and R 8 represent a C 1 -C 10 alkyl group or the like; R 3 , R 4 , R 5 , R 6 , R 9 , R 10 , R 11 , and R 12 represent a hydrogen atom, a C 1 -C 6 alkyl group, an aryl group or the like; X 1 and X 2 represent a C 1 -C 15 alkyl group or an aryl group and X 1 and X 2 in total have 0 to 4 carboxyl groups; m 1 , m 2 , and m 3 represents 0 or 1; L 1 to L 7 independently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.