(4R,6S)-6-[(E)-2-(4,6,7,8-tetraphenoxyquinoline-3-yl)ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one | 1039360-53-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (4R,6S)-6-[(E)-2-(4,6,7,8-tetraphenoxyquinoline-3-yl)ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one
• 英文别名: (4R,6S)-4-hydroxy-6-[(E)-2-(4,6,7,8-tetraphenoxyquinolin-3-yl)ethenyl]oxan-2-one
• CAS: 1039360-53-6
• 化学式: C₄₀H₃₁NO₇
• 分子量: 637.689
• InChiKey: YKHAYLFYRGALRI-XZYQIFJCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  48
• 可旋转键数：
  10
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  96.3
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (4R,6S)-6-[(E)-2-(4,6,7,8-tetraphenoxyquinoline-3-yl)ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 在 potassium hydroxide 、 盐酸 、 calcium acetate 作用下， 以 甲基叔丁基醚 、 水 为溶剂， 反应 8.0h， 以81%的产率得到
  参考文献：
  名称：

  US2011/21561

  摘要：

  公开号：

文献信息

• Synthesis and Anti-Hypercholesterolemic Evaluations of Calcium Salts of 4-Substituted Quinoline-Based Mevalonic Acid
  作者：Qun Hao、Zhengyan Cai、Jing Pan、Yongjia Li、Yuye Xia、Yang Min、Yuchen Sheng、Weicheng Zhou

  DOI：10.1111/j.1747-0285.2011.01198.x

  日期：2011.10

  A series of calcium (3R,5S,6E)‐7‐[4,6,7,8‐substituted‐quinoline‐3‐yl]‐3,5‐dihydroxy‐hept‐6‐enoates was synthesized from the lactones, and the anti‐hypercholesterolemic evaluation in quails was presented in this report. It was found that most of the compounds significantly decreased levels of total cholesterol and low‐density lipoprotein. 2e showed better hypolipidemic effect than atorvastatin, and 2d and 2j exhibited comparable efficacy to atorvastatin. These three compounds were selected as the hypocholesterolemic candidates for further evaluation.