4'-chloro-2-methoxy-5-nitro<1,1'-biphenyl> | 85841-97-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-chloro-2-methoxy-5-nitro<1,1'-biphenyl>
• 英文别名: 4-chloro-2'-methoxy-4'-nitrobiphenyl；2-(4-Chlorophenyl)-1-methoxy-4-nitrobenzene
• CAS: 85841-97-0
• 化学式: C₁₃H₁₀ClNO₃
• 分子量: 263.68
• InChiKey: NUUPESKJDLQVJG-UHFFFAOYSA-N

物化性质

• 熔点：
  127 °C
• 沸点：
  381.8±32.0 °C(Predicted)
• 密度：
  1.302±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4'-chloro-2-methoxy-5-nitro<1,1'-biphenyl> 在 镍 氢气 、 三溴化硼 、 铜 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 8.5h， 生成 4,4'''-dichloro<1,1':3',1'':3'',1'''-quaterphenyl>-4'',6'-diol
  参考文献：
  名称：

  Hung; Werbel, European Journal of Medicinal Chemistry, 1983, vol. 18, # 1, p. 61 - 66

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯苯基丙酮 在 sodium hydroxide 、 sodium hydride 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 4'-chloro-2-methoxy-5-nitro<1,1'-biphenyl>
  参考文献：
  名称：

  Hung; Werbel, European Journal of Medicinal Chemistry, 1983, vol. 18, # 1, p. 61 - 66

  摘要：

  DOI：

文献信息

• A Multi-Task Palladium Catalyst Involved in Heck-Reduction-Cyclization Sequences for the Preparation of 4-Benzyl-1,2-dihydroisoquinolin-3-ones: An Unusual Homogeneous-Heterogeneous Sustainable Approach
  作者：François-Xavier Felpin、Julia Laudien、Eric Fouquet、Cécile Zakri

  DOI：10.1055/s-0029-1219926

  日期：2010.6

  A mixed homogeneous-heterogeneous catalysis that exploits a multi-task palladium catalyst has been developed for one-pot sequential Heck-reduction-cyclization (HRC) reactions leading to novel 4-benzyl-1,2-dihydroisoquinolin-3-ones. The HRC sequence requires mild conditions and allows the separation of the palladium residues under the form of an in situ generated Pd(0)/C catalyst by simple filtration. The homemade and recovered catalyst can be efficiently reused for Suzuki-Miyaura reactions and reductive processes making it useful for sustainable chemistry.

  开发了一种利用多功能钯催化剂的混合均相-非均相催化，用于一步法顺序的Heck-还原-环化（HRC）反应，从而合成新型4-苄基-1,2-二氢异喹啉-3-酮。HRC反应序列在温和条件下进行，并允许通过简单过滤将钯残留物以原位生成的Pd(0)/C催化剂形式分离。自制的回收催化剂可以高效地重复用于铃木-宫浦反应和还原过程，使其在可持续化学中具有重要价值。
• Improved Suzuki-Miyaura Reactions of Aryldiazonium Salts with Boronic Acids by Tuning Palladium on Charcoal Catalyst Properties
  作者：François-Xavier Felpin、Eric Fouquet、Cécile Zakri

  DOI：10.1002/adsc.200800783

  日期：2009.3

  Abstractmagnified imageAn improved Suzuki–Miyaura cross‐coupling reaction of aryldiazonium tetrafluoroborates with boronic acids catalyzed by a highly active palladium catalyst supported on charcoal is described as an extremely practical and efficient protocol. A properties‐activity study of various catalysts clearly established that the optimal catalytic activity was obtained with palladium nanoparticles having a low oxidation degree and uniformly dispersed on the charcoal. The optimized reaction conditions allow the cross‐coupling to proceed at room temperature without any base and ligand in technical grade methanol. Although the catalyst could not be recycled, the low palladium contamination of the solvent and product after a simple filtration of the palladium on charcoal (Pd/C) renders the present protocol competitive and safer for the environment compared to more conventional homogeneous conditions. We have highlighted the efficiency of this novel protocol by a short synthesis of the fungicide Boscalid®.
• New non peptidic C5a receptor antagonists
  作者：Peter C. Astles、Thomas J. Brown、Paul Cox、Frank Halley、Peter M. Lockey、Clive McCarthy、Iain M. McLay、Tahir N. Majid、Andrew D. Morley、Barry Porter、Andrew J. Ratcliffe、Roger J.A. Walsh

  DOI：10.1016/s0960-894x(97)00124-8

  日期：1997.1

  A series of phenylguanidines which bind to the C5a receptor has been developed. The lead compound 1 (IC50=30 mu M), discovered through random screening, has been modified to provide 32 (RPR121154) with submicromolar activity. This compound was shown to further elicit functional antagonism in a human neutrophil C5a stimulated respiratory burst assay. (C) 1997 Elsevier Science Ltd.
• HUNG, J.;WERBEL, L. M., EUR. J. MED. CHEM.-CHIM. THER., 1983, 18, N 1, 61-66
  作者：HUNG, J.、WERBEL, L. M.

  DOI：——

  日期：——