Fmoc-Ser(tbu)-Ala-Pro-Pro-Pro-Arg(Pbf)Lys(Boc)-OH | 1454599-00-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fmoc-Ser(tbu)-Ala-Pro-Pro-Pro-Arg(Pbf)Lys(Boc)-OH
• CAS: 1454599-00-8
• 化学式: C₇₀H₉₉N₁₁O₁₆S
• 分子量: 1382.69
• InChiKey: KBEVIMDMBDLPOT-BURWVIGWSA-N

反应信息

• 作为反应物：
  描述：

  Fmoc-Ser(tbu)-Ala-Pro-Pro-Pro-Arg(Pbf)Lys(Boc)-OH 在 N-甲基吗啉 、 O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate 、 氯化铵 作用下， 以 二氯甲烷 为溶剂， 生成 Fmoc-Ser(tbu)-Ala-Pro-Pro-Pro-Arg(Pbf)Lys(Boc)-NH₂
  参考文献：
  名称：

  Synthesis of novel peptides through Ugi-ligation and their anti-cancer activities

  摘要：

  Proline-rich heptapeptide was synthesized and its structure was modified through Ugi-ligation. The desired pseudopeptides were separated as diastereomers and their anti-cancer activities were investigated. Their in vitro anti-cancer activities were investigated by treating HL60 (leukemia cancer cells), MCF7 (breast cancer cells) and A549 (lung cancer cells) cells with appropriate amounts of synthesized peptides. Our in vitro studies suggest that compounds 11a-b, 11i-j, and 11e had little or no effect on cancer cells viabilities.

  DOI：

  10.1007/s00726-013-1554-5