2-(Propan-2-yloxy)pyridin-3-ol | 1231977-15-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(Propan-2-yloxy)pyridin-3-ol
• 英文别名: 2-propan-2-yloxypyridin-3-ol
• CAS: 1231977-15-3
• 化学式: C₈H₁₁NO₂
• mdl: MFCD16997444
• 分子量: 153.181
• InChiKey: AEKPFESCTCGDEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-溴-1,1-二氟乙烯 、 2-(Propan-2-yloxy)pyridin-3-ol 在 potassium hydroxide 作用下， 以 水 、 乙腈 为溶剂， 反应 0.03h， 生成 、 3-(2-bromo-1,1-difluoroethoxy)-2-isopropoxypyridine
  参考文献：
  名称：

  Synthesis of α,α-Difluoroethyl Aryl and Heteroaryl Ethers

  摘要：

  Fluorine plays a critical role in modern medicinal chemistry due to its unique properties, and new methods for its incorporation into target molecules are of high interest. An efficient new method for the preparation of aryl-alpha,alpha-difluoroethyl ethers (4) via addition of aryl and heteroaryl alcohols (1) to commercially available 2-bromo-1,1-difluoroethene (2) and subsequent hydrogenolysis is presented. This procedure is an attractive alternative to existing methods that employ harshly reactive fluorinating systems such as xenon difluoride and hydrogen fluoride.

  DOI：

  10.1021/ol301696x

文献信息

• Synthesis of α,α-Difluoroethyl Aryl and Heteroaryl Ethers
  作者：Eddie Yang、Matthew R. Reese、John M. Humphrey

  DOI：10.1021/ol301696x

  日期：2012.8.3

  Fluorine plays a critical role in modern medicinal chemistry due to its unique properties, and new methods for its incorporation into target molecules are of high interest. An efficient new method for the preparation of aryl-alpha,alpha-difluoroethyl ethers (4) via addition of aryl and heteroaryl alcohols (1) to commercially available 2-bromo-1,1-difluoroethene (2) and subsequent hydrogenolysis is presented. This procedure is an attractive alternative to existing methods that employ harshly reactive fluorinating systems such as xenon difluoride and hydrogen fluoride.