(E)-2,3-dihydroxypropyl 2-cyano-3-(2-(piperidin-1-yl)naphthalene-6-yl)acrylate | 1290035-80-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-2,3-dihydroxypropyl 2-cyano-3-(2-(piperidin-1-yl)naphthalene-6-yl)acrylate
• 英文别名: 2,3-dihydroxypropyl (E)-2-cyano-3-(6-piperidin-1-ylnaphthalen-2-yl)prop-2-enoate
• CAS: 1290035-80-1
• 化学式: C₂₂H₂₄N₂O₄
• 分子量: 380.444
• InChiKey: LOLUCODUNMZFPF-YBFXNURJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  93.8
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (E)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-3-(2-(piperidin-1-yl)naphthalene-6-yl)acrylate 在 甲醇 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 以84%的产率得到(E)-2,3-dihydroxypropyl 2-cyano-3-(2-(piperidin-1-yl)naphthalene-6-yl)acrylate
  参考文献：
  名称：

  [EN] AMYLOID BINDING AGENTS
  [FR] AGENTS DE LIAISON AUX AMYLOÏDES

  摘要：

  公开号：

  WO2011072257A3

文献信息

• AMYLOID BINDING AGENTS
  申请人：The Regents of the University of California

  公开号：US20150177262A1

  公开（公告）日：2015-06-25

  There are provided compounds and methods for the detection of amyloids and treatment of diseases related to amyloids including Alzheimer's disease and other related amyloid-based neurodegenerative diseases.

  提供了化合物和方法，用于检测淀粉样蛋白和治疗与淀粉样蛋白相关的疾病，包括阿尔茨海默病和其他相关的淀粉样蛋白相关神经退行性疾病。
• Methods of preparing ophthalmic formulations and uses of same
  申请人：Cognoptix, Inc.

  公开号：US10350309B2

  公开（公告）日：2019-07-16

  The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.

  本发明涉及一种制备软膏的工艺，包括将荧光分子转子化合物、矿物油和研磨介质的混合物进行球磨搅拌，并将该混合物与软膏的疏水性载体结合。本发明还涉及一种眼科制剂，该制剂包含一种药学上可接受的载体和一种结构式（I）如下的化合物或其药学上可接受的盐： 结构式（I）中各变量的值和优选值在此描述。
• Methods of Preparing Ophthalmic Formulations and Uses of Same
  申请人：Cognoptix, Inc.

  公开号：US20150118163A1

  公开（公告）日：2015-04-30

  The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.
• Method for Measuring Fluorescence in Ocular Tissue
  申请人：COGNOPTIX, INC.

  公开号：US20160278677A1

  公开（公告）日：2016-09-29

  A method is provided for ophthalmic measurements, wherein the amount of a fluorophore is detected in ocular tissue and the obtained fluorescence signals are normalized by per-forming a ratio.
• US8940918B2
  申请人：——

  公开号：US8940918B2

  公开（公告）日：2015-01-27