2-(2,4-dihydroxyphenyl)-2,3-dihydroquinolin-4(1H)-one | 1354631-69-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(2,4-dihydroxyphenyl)-2,3-dihydroquinolin-4(1H)-one
• 英文别名: 2-(2,4-dihydroxyphenyl)-2,3-dihydro-1H-quinolin-4-one
• CAS: 1354631-69-8
• 化学式: C₁₅H₁₃NO₃
• 分子量: 255.273
• InChiKey: VHCRORMZECDUMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻氨基苯乙酮 、 2,4-二羟基苯甲醛 在 L-脯氨酸 作用下， 以 甲醇 为溶剂， 反应 48.0h， 生成 2-(2,4-dihydroxyphenyl)-2,3-dihydroquinolin-4(1H)-one
  参考文献：
  名称：

  aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle

  摘要：

  aza-Flavanones have been identified as a new class of selective microRNA inhibitors. These compounds were found to arrest cell cycle via a novel cross species microRNA-dependent regulatory pathway interpreting an unexpected link between cell cycle arrest and microRNA mediated control in cancer. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.10.061

文献信息

• aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle
  作者：Srivari Chandrasekhar、Sreerangam N.C.V.L. Pushpavalli、Srinivas Chatla、Debasmita Mukhopadhyay、Bogonda Ganganna、Kandi Vijeender、Pabbaraja Srihari、Chada Raji Reddy、M. Janaki Ramaiah、Utpal Bhadra

  DOI：10.1016/j.bmcl.2011.10.061

  日期：2012.1

  aza-Flavanones have been identified as a new class of selective microRNA inhibitors. These compounds were found to arrest cell cycle via a novel cross species microRNA-dependent regulatory pathway interpreting an unexpected link between cell cycle arrest and microRNA mediated control in cancer. (C) 2011 Elsevier Ltd. All rights reserved.
• <i>Aza</i>-Flavanone Diminishes Parkinsonism in the <i>Drosophila melanogaster</i> <i>Parkin</i> Mutant
  作者：Chitrakshi Pant、Moumita Chakrabarti、Jolly Janette Mendonza、Bogonda Ganganna、Srihari Pabbaraja、Manika Pal Bhadra

  DOI：10.1021/acschemneuro.1c00285

  日期：2021.12.1