cyclo[5-(6-O-benzyl-β-D-galactofuranozyl)-(1->6)-(β-D-galactofuranozyl)-1->]4 | 1033706-88-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cyclo[5-(6-O-benzyl-β-D-galactofuranozyl)-(1->6)-(β-D-galactofuranozyl)-1->]4
• CAS: 1033706-88-5
• 化学式: C₇₆H₁₀₄O₄₀
• 分子量: 1657.64
• InChiKey: ZIKVUKBBXWMGAC-DXJJIKATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.51
• 重原子数：
  116.0
• 可旋转键数：
  16.0
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  589.2
• 氢给体数：
  20.0
• 氢受体数：
  40.0

反应信息

• 作为反应物：
  描述：

  cyclo[5-(6-O-benzyl-β-D-galactofuranozyl)-(1->6)-(β-D-galactofuranozyl)-1->]4 在 10% Pd on charcoal 、 氢气 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 反应 24.0h， 以59%的产率得到cyclo[5-(6-β-D-galactofuranozyl)-(1->6)-(β-D-galactofuranozyl)-1->]4
  参考文献：
  名称：

  Chemical Synthesis of Cyclic Galactooligofuranosides Isolated from Enzymatic Degradation Products of Cell Wall Arabinogalactan of Mycobacterium tuberculosis

  摘要：

  Synthesis of cyclic tetra-, hexa- and octasaccharides containing alternating (1 -> 5)-,beta- and (1 -> 6)-beta-galactofuranosyl linkages has been achieved by intramolecular cycloglycosylation of corresponding linear sugars and by cyclooligomerization of 1,6-linked and 1,5-linked disaccharides. In particular,cyclooligornerization of the (1 -> 6)-beta-galactofuranosyl disaccharide provides an efficient way to secure all three cyclic sugars in one operation.

  DOI：

  10.1021/ol800530u
• 作为产物：
  描述：

  2'-(benzyloxycarbonyl)benzyl (2,3,5-tri-O-benzoyl-β-D-galactofuranosyl)-(1->5)-(2,3-di-O-benzoyl-6-O-benzyl-β-D-galactofuranosyl)-(1->6)-(2,3,5-tri-O-benzoyl-β-D-galactofuranosyl)-(1->5)-2,3-di-O-benzoyl-6-O-benzyl-β-D-galactofuranoside 、 2'-carboxybenzyl (2,3,5-tri-O-benzoyl-6-O-t-butyldimethylsilyl-β-D-galactofuranosyl)-(1->5)-(2,3-di-O-benzoyl-6-O-benzyl-β-D-galactofuranosyl)-(1->6)-(2,3,5-tri-O-benzoyl-β-D-galactofuranosyl)-(1->5)-2,3-di-O-benzoyl-6-O-benzyl-β-D-galactofuranoside 在 2,6-二叔丁基-4-甲基吡啶 、 三氟甲磺酸酐 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以12 mg的产率得到cyclo[5-(6-O-benzyl-β-D-galactofuranozyl)-(1->6)-(β-D-galactofuranozyl)-1->]4
  参考文献：
  名称：

  Chemical Synthesis of Cyclic Galactooligofuranosides Isolated from Enzymatic Degradation Products of Cell Wall Arabinogalactan of Mycobacterium tuberculosis

  摘要：

  Synthesis of cyclic tetra-, hexa- and octasaccharides containing alternating (1 -> 5)-,beta- and (1 -> 6)-beta-galactofuranosyl linkages has been achieved by intramolecular cycloglycosylation of corresponding linear sugars and by cyclooligomerization of 1,6-linked and 1,5-linked disaccharides. In particular,cyclooligornerization of the (1 -> 6)-beta-galactofuranosyl disaccharide provides an efficient way to secure all three cyclic sugars in one operation.

  DOI：

  10.1021/ol800530u