5-Aza-cytidin-5'-triphosphat | 2226-74-6

• 物质功能分类: 医药中间体 - 嘧啶类化合物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Aza-cytidin-5'-triphosphat
• 英文别名: 4-amino-1-(O⁵-tetrahydroxytriphosphoryl-β-D-ribofuranosyl)-1H-[1,3,5]triazin-2-one；5-Azacytidine triphosphate；[[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 2226-74-6
• 化学式: C₈H₁₅N₄O₁₄P₃
• 分子量: 484.147
• InChiKey: KFILMUPGQGKFKE-KVTDHHQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  281
• 氢给体数：
  7
• 氢受体数：
  14

文献信息

• [EN] USE OF A DHODH INHIBITOR IN COMBINATION WITH AN INHIBITOR OF PYRIMIDINE SALVAGE<br/>[FR] UTILISATION D'UN INHIBITEUR DE DHODH EN ASSOCIATION AVEC UN INHIBITEUR DE RÉCUPÉRATION PYRIMIDIQUE
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2017117006A1

  公开（公告）日：2017-07-06

  Compounds and methods are provided for the treatment of pathogenic virus infections or cancer. The formulations combine an inhibitor of de novo pyrimidine synthesis, and an inhibitor of a pyrimidine salvage pathway enzyme.

  提供了用于治疗病原病毒感染或癌症的化合物和方法。该配方组合了一种新生嘧啶合成抑制剂和一种嘧啶救助途径酶抑制剂。
• Use of a DHODH inhibitor in combination with an inhibitor of pyrimidine salvage
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10736911B2

  公开（公告）日：2020-08-11

  Compounds and methods are provided for the treatment of pathogenic virus infections or cancer. The formulations combine an inhibitor of de novo pyrimidine synthesis, and an inhibitor of a pyrimidine salvage pathway enzyme.

  本研究提供了用于治疗致病病毒感染或癌症的化合物和方法。这些制剂结合了一种嘧啶从头合成抑制剂和一种嘧啶挽救途径酶抑制剂。
• RNA encoding a therapeutic protein
  申请人：CureVac AG

  公开号：US11078247B2

  公开（公告）日：2021-08-03

  The present invention relates to an RNA encoding a therapeutic protein. In particular, the present invention relates to RNA suitable for use as a medicament. The present invention concerns such novel RNA as well as compositions and kits comprising the RNA. Furthermore, the present invention relates to the RNA, compositions or kits as disclosed herein for use as a medicament. The present invention also provides the use of the RNA, compositions or kits as disclosed herein far increasing the expression of said encoded protein, in particular in gene therapy.

  本发明涉及一种编码治疗蛋白质的 RNA。特别是，本发明涉及适合用作药物的 RNA。本发明涉及这种新型 RNA 以及包含该 RNA 的组合物和试剂盒。此外，本发明还涉及本文公开的用作药物的 RNA、组合物或试剂盒。本发明还提供了本文所公开的 RNA、组合物或试剂盒在提高所述编码蛋白表达量方面的用途，特别是在基因治疗中的用途。
• PROCEDE DE PREPARATION DE NUCLEOTIDES ET ANALOGUES A FAÇON PAR SYNTHESE SUR SUPPORT SOLUBLE ET OUTILS BIOLOGIQUES PREPARES
  申请人：Centre National de la Recherche Scientifique

  公开号：EP2265624A1

  公开（公告）日：2010-12-29
• METHOD FOR PREPARING NUCLEOTIDES AND RELATED ANALOGUES BY SYNTHESIS ON SOLUBLE SUBSTRATE, AND BIOLOGICAL TOOLS THUS PREPARED
  申请人：Peyrottes Suzanne

  公开号：US20110118454A1

  公开（公告）日：2011-05-19

  The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.