3-(4-methoxyphenyl)-N-(2-methylquinolin-8-yl)propanamide | 438457-02-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(4-methoxyphenyl)-N-(2-methylquinolin-8-yl)propanamide
• CAS: 438457-02-4
• 化学式: C₂₀H₂₀N₂O₂
• mdl: MFCD03388908
• 分子量: 320.391
• InChiKey: NODBJFYQYVUCCT-UHFFFAOYSA-N

物化性质

• 沸点：
  563.3±45.0 °C(Predicted)
• 密度：
  1.198±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  8-氨基喹哪啶 、 4-甲氧基苯丙酰氯 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成 3-(4-methoxyphenyl)-N-(2-methylquinolin-8-yl)propanamide
  参考文献：
  名称：

  QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE

  摘要：

  本文提供了喹啉，例如Formula I的化合物，其药物组合物，以及用于治疗、预防或缓解神经疾病、神经退行性疾病或糖尿病的一种或多种症状的方法。本文还提供了用于调节肌浆网/内质网C2+ATP酶活性的方法。

  公开号：

  US20190151303A1

文献信息

• [EN] QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES<br/>[FR] QUINOLÉINES ET LEUR UTILISATION POUR TRAITER LES MALADIES DUES AU STRESS DU RÉTICULUM ENDOPLASMIQUE
  申请人：CELLADON CORP

  公开号：WO2016032569A1

  公开（公告）日：2016-03-03

  Provided herein are quinolines, e.g., a compound of Formula (I) or (IB), pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase.

  本文提供了喹啉类化合物，例如，化合物的化学式为（I）或（IB），以及其药物组合物，并用于治疗、预防或改善内质网应激引起的一种或多种疾病症状的方法。本文还提供了用于减少内质网应激并调节肌浆/内质网Ca2+ ATP酶活性的方法。
• Quinolines that modulate SERCA and their use for treating disease
  申请人：Dahl Russell

  公开号：US10772881B2

  公开（公告）日：2020-09-15

  Provided herein are quinolines, e.g., a compound of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a neurological disease, neurodegenerative disorder, or diabetes. Also provided herein are methods of their use for modulating the activity of a sarcoplasmic/endoplasmic reticulum C2+ ATPase.

  本文提供了喹啉类化合物，例如式 I 的化合物，其药物组合物，以及使用它们治疗、预防或改善神经系统疾病、神经退行性疾病或糖尿病的一种或多种症状的方法。本文还提供了它们用于调节肌浆/内质网 C2+ ATP 酶活性的方法。
• QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES
  申请人：EIGER BIOPHARMACEUTICALS, INC.

  公开号：US20170281611A1

  公开（公告）日：2017-10-05

  Provided herein are quinolines, e.g., a compound of Formula (I) or (IB), pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase.
• [EN] METHODS RELATED TO ACTIVATION OF THE BONE MORPHOGENIC PROTEIN SIGNALING PATHWAY<br/>[FR] MÉTHODES LIÉES À L'ACTIVATION DE LA VOIE DE SIGNALISATION DES PROTÉINES MORPHOGÉNÉTIQUES OSSEUSES
  申请人：ST JUDE CHILDRENS RES HOSPITAL

  公开号：WO2019005563A1

  公开（公告）日：2019-01-03

  In one aspect, compounds and compositions that activate BMP signaling and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with diminished BMP signaling such as, for example, cancer, juvenile polyposis syndrome, hereditary pulmonary arterial hypertension, obesity osteosporosis, and chronic kidney disease. The disclosed compounds and compositions can also be useful in cartilage repair and bone formation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.