4-(p-fluorophenyl)-5,6,7-trihydroxy-2(1H)-quinolinone | 1402932-09-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(p-fluorophenyl)-5,6,7-trihydroxy-2(1H)-quinolinone
• 英文别名: 4-(4-fluorophenyl)-5,6,7-trihydroxy-1H-quinolin-2-one
• CAS: 1402932-09-5
• 化学式: C₁₅H₁₀FNO₄
• 分子量: 287.247
• InChiKey: TWAUFZOKDVLEJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.8
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-氟苯甲酰乙酸乙酯 在 吡啶 作用下， 以 吡啶 为溶剂， 反应 0.33h， 生成 4-(p-fluorophenyl)-5,6,7-trihydroxy-2(1H)-quinolinone
  参考文献：
  名称：

  Synthesis and Evaluation of 4-Aryl-2(1H)-quinolinones as Potent Amyloid β Fibrillogenesis Inhibitors

  摘要：

  4-Aryl-2(1H)-quinolinones were synthesized and evaluated in vitro as inhibitors of A beta(1-42) fibrillogenesis using a thioflavin T fluorescence method. The most potent anti-aggregating molecules (4b and 5c) were found among the derivatives bearing OH and/or OMe groups at C-4' (R-4) and/or C-6 (R-2) of the 4-aryl-2(1H)-quinolinone moiety. Furthermore, the derivative bearing 4'-F substituent (4f) proved to be a very active inhibitor.

  DOI：

  10.3987/com-12-12506

文献信息

• Synthesis and Evaluation of 4-Aryl-2(1H)-quinolinones as Potent Amyloid β Fibrillogenesis Inhibitors
  作者：Masayoshi Tsubuki、Yoko Shimokawa、Masamichi Nakakoshi、Setsu Saito、Hideharu Suzuki、Yuusaku Yokoyama、Akihito Ishigami、Hideo Nishioka

  DOI：10.3987/com-12-12506

  日期：——

  4-Aryl-2(1H)-quinolinones were synthesized and evaluated in vitro as inhibitors of A beta(1-42) fibrillogenesis using a thioflavin T fluorescence method. The most potent anti-aggregating molecules (4b and 5c) were found among the derivatives bearing OH and/or OMe groups at C-4' (R-4) and/or C-6 (R-2) of the 4-aryl-2(1H)-quinolinone moiety. Furthermore, the derivative bearing 4'-F substituent (4f) proved to be a very active inhibitor.