4-(pyrimidin-5-yloxy)quinazoline | 1134120-38-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(pyrimidin-5-yloxy)quinazoline
• 英文别名: 4-pyrimidin-5-yloxyquinazoline
• CAS: 1134120-38-9
• 化学式: C₁₂H₈N₄O
• 分子量: 224.222
• InChiKey: ZBZQAPSIWWYWGR-UHFFFAOYSA-N

物化性质

• 沸点：
  412.0±20.0 °C(Predicted)
• 密度：
  1.342±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)quinazoline 、 5-嘧啶硼酸 在 四(三苯基膦)钯 、 氧气 、 caesium carbonate 作用下， 以 乙二醇二甲醚 为溶剂， 反应 10.0h， 以78%的产率得到4-(pyrimidin-5-yloxy)quinazoline
  参考文献：
  名称：

  Wacharasindhu, Sumrit; Bardhan, Sujata; Wan, Zhao-Kui, Journal of the American Chemical Society, 2009, vol. 131, p. 4174 - 4175

  摘要：

  DOI：

文献信息

• HETEROARYL ETHERS AND PROCESSES FOR THEIR PREPARATION
  申请人：Mansour Tarek Suhayl

  公开号：US20090291971A1

  公开（公告）日：2009-11-26

  The present invention relates to processes for the preparation of heteroaryl ethers. In some embodiments, the processes relate to cross coupling reactions between triazol-1-yloxy and triazol-1-yl heterocycles with aryl boronic acids. In a further aspect, this invention also relates to compounds that are useful for the treatment of oncological diseases or disorders, and for the treatment of inflammation.

  本发明涉及制备杂环基醚的过程。在某些实施例中，该过程涉及三唑-1-氧基和三唑-1-基杂环与芳基硼酸之间的交叉偶联反应。在进一步的方面，本发明还涉及用于治疗肿瘤疾病或障碍以及治疗炎症的化合物。
• Hydrogen peroxide mediated formation of heteroaryl ethers from pyridotriazol-1-yloxy heterocycles and arylboronic acids
  作者：Sujata Bardhan、Keiko Tabei、Zhao-Kui Wan、Tarek S. Mansour

  DOI：10.1016/j.tetlet.2009.07.135

  日期：2009.10

  Pyridotriazol-1-yloxypyrimidine 3 reacts with arylboronic acids under palladium-free, Cs2CO3, (0.8%) H2O2, and DME conditions to produce heteroaryl ethers 4-16 in good yields comparable to the oxidative palladium-catalyzed reaction. The yields of aryl ethers 17-19 from quinazoline 2 with (0.8%) H2O2 were modest. Hydrogen peroxide is Superior to dioxygen as an oxidant in these reactions. (C) 2009 Elsevier Ltd. All rights reserved.
• [EN] HETEROARYL ETHERS AND PROCESSES FOR THEIR PREPARATION<br/>[FR] HÉTÉROARYL ÉTHERS ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：WYETH CORP

  公开号：WO2009058937A2

  公开（公告）日：2009-05-07

  The present invention relates to processes for the preparation of of heteroaryl ethers. In some embodiments, the processes relate to cross coupling reactions between triazol-1-yloxy and triazol-1-yl heterocycles with aryl boronic acids. In a further aspect, this invention also relates to compounds that are useful for the treatment of oncological diseases or disorders, and for the treatment of inflammation.
• Wacharasindhu, Sumrit; Bardhan, Sujata; Wan, Zhao-Kui, Journal of the American Chemical Society, 2009, vol. 131, p. 4174 - 4175
  作者：Wacharasindhu, Sumrit、Bardhan, Sujata、Wan, Zhao-Kui、Tabei, Keiko、Mansour, Tarek S.

  DOI：——

  日期：——