8-chloro-5,6,7,8-tetrahydroquinoline hydrochloride | 114432-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-chloro-5,6,7,8-tetrahydroquinoline hydrochloride
• 英文别名: 8-chloro-5,6,7,8-tetrahydroquinoline;hydrochloride
• CAS: 114432-00-7
• 化学式: C₉H₁₀ClN*ClH
• 分子量: 204.099
• InChiKey: CIIMLMHZIAAHJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.12
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  12.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  8-chloro-5,6,7,8-tetrahydroquinoline hydrochloride 、 4-巯基苯甲腈 在 potassium carbonate 作用下， 以 N-甲基乙酰胺 为溶剂， 以4.72 g (89%)的产率得到4-(5,6,7,8-tetrahydroquinoline-8-ylthio)-benzonitrile
  参考文献：
  名称：

  8-phenylthio-tetrahydroquinolines and anti-allergic use thereof

  摘要：

  从8-苯硫基四氢喹啉的公式中选择的化合物，其公式为##STR1##其中R.sub.1和R.sub.2分别选择自氢，卤素，1到6个碳原子的烷基（可选择性地取代羟基，1到6个碳原子的烷氧基，1到6个碳原子的烷酰氧基，2到6个碳原子的烷氧羰基，-OH，-NO.sub.2，-NH.sub.2，-COOH，-CN和氨基磺酰基）或当R.sub.1和R.sub.2在相邻的碳原子上时，与所述碳原子形成苯基，以及它们的非毒性，药用酸盐，具有抗过敏活性。

  公开号：

  US04847268A1
• 作为产物：
  描述：

  8-氯-5,6,7,8-四氢喹啉 生成 8-chloro-5,6,7,8-tetrahydroquinoline hydrochloride
  参考文献：
  名称：

  CLEMENCE, FRANCOIS;FORTIN, MICHEL;LE, MARTRET ODILE;DELEVALLEE, FRANCOISE

  摘要：

  DOI：

文献信息

• Pyridine derivatives
  申请人：John Wyeth & Brother Limited

  公开号：US05001131A1

  公开（公告）日：1991-03-19

  The invention provides a method of relieving inflammation in a mammal inflicted with an imflammatory disease which method comprises treating said mammal with a therapeutically effective amount of a compound of formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, loweralkyl, cycloloweralkyl, loweralkoxy, carboxy, hydroxyloweralkyl, halogen, haloloweralkyl, loweralkoxycarbonyl, aryl or aralkyl or 7-12 carbon atoms, or R.sup.1 and R.sup.2 taken together, or R.sup.2 and R.sup.3 taken together form a5,6, or 7 membered ring with the carbon atoms to which they are attached, which ring may be saturated or unsaturated and unsubstituted or substituted by loweralkyl or loweralkoxy, R.sup.4 represents hydrogen, loweralkyl, loweralkoxy, aryl or aralkyl of 7-12 carbon atoms, n is 1,2 or 3, m is 1,2 or 3, Ar represents phenyl which may be substituted by halogen, loweralkyl, loweralkoxy, haloloweralkyl, haloloweralkoxy, nitro, amino; cyano, loweralkylamino, diloweralkylamino, carboxy, loweralkoxycarbonyl, loweralkanoyl, loweralkanoylamino, aryl or aminoloweralkyl, X is NHSO.sub.2, NH, NHCO--, CH(OH), O, CO, S, SO or SO.sub.2, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种缓解患有炎症性疾病的哺乳动物炎症的方法，该方法包括用治疗有效量的式I化合物处理所述哺乳动物，其中R1、R2和R3代表氢、低级烷基、环低级烷基、低级烷氧基、羧基、羟基低级烷基、卤素、卤代低级烷基、低级烷氧羰基、芳基或芳烷基或7-12个碳原子，或者R1和R2一起，或者R2和R3一起与其所连接的碳原子形成5、6或7元环，该环可以是饱和的或不饱和的，并且未取代或被低级烷基或低级烷氧基取代，R4代表氢、低级烷基、低级烷氧基、芳基或芳烷基，含有7-12个碳原子，n是1、2或3，m是1、2或3，Ar代表苯基，其可以被卤素、低级烷基、低级烷氧基、卤代低级烷基、卤代低级烷氧基、硝基、氨基、氰基、低级烷基氨基、二低级烷基氨基、羧基、低级烷氧羰基、低级烷酰基、低级烷酰氨基、芳基或氨基低级烷基取代，X是NHSO2、NH、NHCO--、CH(OH)、O、CO、S、SO或SO2，或其药学上可接受的盐。
• Decahydroquinolines and analgesic use thereof
  申请人：Roussel Uclaf

  公开号：US04816465A1

  公开（公告）日：1989-03-28

  Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected form a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceutically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.

  该专利描述了十氢喹啉的对映异构体和二对映异构体，化学式为##STR1##其中R.sub.1和R.sub.2分别选择自氢和1到5个碳原子的烷基，或与它们连接的氮原子一起形成一个5到6个成员的杂环，该杂环可以包括另一个杂原子，并且可以选择性地被取代；A从--(CH.sub.2).sub.n--和烷基取代的含有2到8个碳原子的烷基中选择，n是0到5的整数；Z从可选择性地取代的苯基，萘基，茚基，5到6个成员的单环杂环和双环杂环中选择，所有这些都未取代或被一个或多个取代基取代，以及其非毒性、药学上可接受的酸盐和季铵盐，具有中央镇痛作用。
• 8-amino decahydroquinolines having central nervous system analgesic
  申请人：Roussel Uclaf

  公开号：US04968700A1

  公开（公告）日：1990-11-06

  Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected form a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceuically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.

  化合物的新对映异构体和顺反异构体，其化学式为##STR1##其中R.sub.1和R.sub.2分别选自氢和1到5个碳原子的烷基的群体，或与它们连接的氮原子共同形成一个5到6个成员的杂环，该杂环可包括另一个杂原子，并可选择性地被取代，A选自--(CH.sub.2).sub.n --和被烷基取代且具有2到8个碳原子的烷基，n为0到5的整数，Z选自可选择性取代的苯基、萘基、茚基、5到6个成员的单环杂环和双环杂环，所有这些均未被取代或被一个或多个取代基取代，以及它们的无毒、药学上可接受的酸盐和季铵盐，具有中枢镇痛作用。
• Novel hydroquinolines useful as intermediates
  申请人：Roussel Uclaf

  公开号：US04988810A1

  公开（公告）日：1991-01-29

  Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected from a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceutically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.

  该专利描述了一种新的十氢喹啉的对映异构体和顺反异构体，其化学式为 ##STR1## 其中R.sub.1和R.sub.2分别选自氢和1至5个碳原子的烷基的群体，或者与它们连接的氮原子一起形成一个5至6个成员的杂环，该杂环可以包括另一个杂原子，并且可以选择性地被取代，A选自--(CH.sub.2).sub.n --和被烷基取代的烷基，其具有2至8个碳原子，n为0至5的整数，Z选自可选择性取代的苯基、萘基、茚基、5至6个成员的单环杂环和双环杂环，全部未取代或被一个或多个取代基取代，并具有中枢镇痛作用的非毒性、药学上可接受的酸盐和季铵盐。
• KENNEWELL, PETER DAVID;CLEMENTS-JEWERY, STEPHEN;WESTWOOD, ROBERT
  作者：KENNEWELL, PETER DAVID、CLEMENTS-JEWERY, STEPHEN、WESTWOOD, ROBERT

  DOI：——

  日期：——