(E)-3-methoxy-4-(oct-4-en-4-yl)pyridine | 1239454-17-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-3-methoxy-4-(oct-4-en-4-yl)pyridine
• 英文别名: 3-methoxy-4-[(E)-oct-4-en-4-yl]pyridine
• CAS: 1239454-17-1
• 化学式: C₁₄H₂₁NO
• 分子量: 219.327
• InChiKey: XBFCYPKPHMREPP-XYOKQWHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-甲氧基吡啶 、 4-辛炔 在 bis(1,5-cyclooctadiene)nickel (0) 、 N-(2-(3-mesityl-2,3-dihydro-1H-imidazol-1-yl)ethyl)-2-methylpropan-2-amine 、 三甲基铝 作用下， 以 正庚烷 、 甲苯 为溶剂， 反应 16.08h， 以89%的产率得到(E)-3-methoxy-4-(oct-4-en-4-yl)pyridine
  参考文献：
  名称：

  Bimetallic Nickel Aluminun Mediated Para-Selective Alkenylation of Pyridine: Direct Observation of η²,η¹-Pyridine Ni(0)−Al(III) Intermediates Prior to C−H Bond Activation

  摘要：

  We have presented new amino-NHC Ni-Al complex mediated para C-H bond activation for pyridine and quinolin, and isolated for the first time the intermediate structure of a bimetallic eta(2),eta(1)-pyridine pyridine nickel aluminum complex prior to its C-H activation, which serves as key evidence for bimetallic catalysis.

  DOI：

  10.1021/ja1061246

文献信息

• Bimetallic Nickel Aluminun Mediated <i>Para</i>-Selective Alkenylation of Pyridine: Direct Observation of η²,η¹-Pyridine Ni(0)−Al(III) Intermediates Prior to C−H Bond Activation
  作者：Chung-Chih Tsai、Wei-Chih Shih、Cyong-Hui Fang、Chia-Yi Li、Tiow-Gan Ong、Glenn P. A. Yap

  DOI：10.1021/ja1061246

  日期：2010.9.1

  We have presented new amino-NHC Ni-Al complex mediated para C-H bond activation for pyridine and quinolin, and isolated for the first time the intermediate structure of a bimetallic eta(2),eta(1)-pyridine pyridine nickel aluminum complex prior to its C-H activation, which serves as key evidence for bimetallic catalysis.