5-[5-formyl-2-(4-morpholino)-4-thiazolyl]-2-(4-morpholino)-4-phenylthiazole | 209050-03-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[5-formyl-2-(4-morpholino)-4-thiazolyl]-2-(4-morpholino)-4-phenylthiazole
• 英文别名: 2-morpholin-4-yl-4-(2-morpholin-4-yl-4-phenyl-1,3-thiazol-5-yl)-1,3-thiazole-5-carbaldehyde
• CAS: 209050-03-3
• 化学式: C₂₁H₂₂N₄O₃S₂
• 分子量: 442.563
• InChiKey: ZULMFSYPGRAKFG-UHFFFAOYSA-N

物化性质

• 沸点：
  653.5±65.0 °C(predicted)
• 密度：
  1.367±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  30.0
• 可旋转键数：
  5.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.79
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  5-[5-formyl-2-(4-morpholino)-4-thiazolyl]-2-(4-morpholino)-4-phenylthiazole 在 哌啶 、 lead(IV) acetate 、 盐酸 、 溶剂黄146 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.17h， 生成 2-[2-Morpholin-4-yl-4-(2-morpholin-4-yl-4-phenyl-1,3-thiazol-5-yl)-1,3-thiazol-5-yl]ethene-1,1,2-tricarbonitrile
  参考文献：
  名称：

  SYNTHESIS AND SOLVATOCHROMIC PROPERTIES OF 5-DICYANOVINYL-AND 5-TRICYANOVINYL-SUBSTITUTED 2-AMINO-THIAZOLES AND 2-AMINO-THIOPHENES

  摘要：

  Starring from 2-morpholinothiazoles 6 and 2-morpholinothiophenes 7 and following known routes several 5-dicyanovinyl and 5-tricyanovinyl-substituted derivatives 10 - 13 have been prepared and their solvatochromic properties estimated.

  DOI：

  10.1080/10426509908031622
• 作为产物：
  描述：

  5-chloroacetyl-2-morpholino-4-phenylthiazole 在 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 5-[5-formyl-2-(4-morpholino)-4-thiazolyl]-2-(4-morpholino)-4-phenylthiazole
  参考文献：
  名称：

  SYNTHESIS AND SOLVATOCHROMIC PROPERTIES OF 5-DICYANOVINYL-AND 5-TRICYANOVINYL-SUBSTITUTED 2-AMINO-THIAZOLES AND 2-AMINO-THIOPHENES

  摘要：

  Starring from 2-morpholinothiazoles 6 and 2-morpholinothiophenes 7 and following known routes several 5-dicyanovinyl and 5-tricyanovinyl-substituted derivatives 10 - 13 have been prepared and their solvatochromic properties estimated.

  DOI：

  10.1080/10426509908031622

文献信息

• Preparation and properties of 2-Dialkylamino-5-haloacetyl-thiazoles and 4-(2-Dialkylamino-5-thiazolyl)-thiazoles
  作者：Cornelia Mokry、Horst Hartmann

  DOI：10.1002/prac.19983400413

  日期：——

  By the reaction of N-acylthioureas 7 with 1,3-dichloroacetone 9 2-dialkylamino-5-chloroacetyl-thiazoles 11 are avialable. These compounds react with thioureas or aryl thioamides under heterocyclisation to give bis-(2-dialkylamino-5-thiazolyl)-ketones 13, 2-aryl-4-(2-dialkylamino-5-thiazolyl)thiazoles 14, or 2-dialkylamino-4-(2-dialkylamino-5-thiazolyl)-thiazoles 15, resp., from which the last-mentioned compound exhibit a high reactivity towards several electrophilic reagents. Thus, deeply colored cyanovinyl, arylazo, and arylmethine substituted bisthiazole dyes 17, 18, and 19, resp., have been formed.