6-bromo-1-ethoxycarbonyl-2-isopropenyl-2,3-dihydroquinolin-4-one | 1104378-57-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-bromo-1-ethoxycarbonyl-2-isopropenyl-2,3-dihydroquinolin-4-one
• CAS: 1104378-57-5
• 化学式: C₁₅H₁₆BrNO₃
• 分子量: 338.201
• InChiKey: ASZDWOZZBXLCKP-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  、 isopropenylmagnesium chloride 在 水 、 氯化铵 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.5h， 以0.074 g的产率得到6-bromo-1-ethoxycarbonyl-2-isopropenyl-2,3-dihydroquinolin-4-one
  参考文献：
  名称：

  Synthesis and antimicrobial activity of 2-alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones and 2-alkenylquinol-4-ones

  摘要：

  2-Alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones, and 2-alkenylquinol-4-ones were prepared with very good regioselectivity by Me3SiOTf-mediated conjugate addition of alkenylmagnesium bromides and alkenyllithium compounds to chromones thiochromones, and quinol-4-ones. A number of products exhibit a considerable antimicrobial activity. The best activity, with respect to the spectrum of antimicrobial activity, was observed for 2-vinylchroman-4-ones containing an unsubstituted vinyl group and a chloride group located at the chromanone moiety. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.10.043