| 1347972-81-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• CAS: 1347972-81-9
• 化学式: C₂₄H₃₀N₄O₂
• 分子量: 406.528
• InChiKey: BRSMUINELNOMOJ-NTCAYCPXSA-N

反应信息

• 作为产物：
  描述：

  在 盐酸羟胺 、 sodium methylate 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Minor structural modifications to Pracinostat produce big changes in its biological responses

  摘要：

  AbstractA series of compounds similar to Pracinostat that contained benzimidazole ring and N‐hydroxyacrylamide attached at 5‐ or 6‐position were designed, synthesized, and evaluated as HDAC inhibitors. It was interesting to find that the corresponding derivative 1 with N‐hydroxyacrylamide attached at 5‐position was a potent HDAC inhibitor while the others at 6‐position were not. This is the first time to demonstrate the position difference plays important role in the HDAC inhibitory activities of the cinnamic hydroxamates.

  DOI：

  10.1111/cbdd.13527