ethyl 2-cyano-3-[2-hydroxy-5-(2-hydroxy-5-prop-2-enylphenyl)-3-prop-2-enylphenyl]prop-2-enoate | 1187954-32-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: ethyl 2-cyano-3-[2-hydroxy-5-(2-hydroxy-5-prop-2-enylphenyl)-3-prop-2-enylphenyl]prop-2-enoate
• CAS: 1187954-32-0
• 化学式: C₂₄H₂₃NO₄
• 分子量: 389.451
• InChiKey: VNPZTOQRGYCJPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.69
• 重原子数：
  29.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  90.55
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  5-formylhonokiol 、 氰乙酸乙酯 以 乙醇 为溶剂， 反应 48.0h， 生成 ethyl 2-cyano-3-[2-hydroxy-5-(2-hydroxy-5-prop-2-enylphenyl)-3-prop-2-enylphenyl]prop-2-enoate
  参考文献：
  名称：

  Semi-synthesis and anti-proliferative activity evaluation of novel analogues of Honokiol

  摘要：

  A series of honokiol analogues were synthesized by modifying the 5- and/or 3'-position(s) of honokiol to assess their anti-tumor effects. Some compounds exerted more potent anti-proliferative activities than those of honokiol on K562 leukemia cells, A549 alveolar basal epithelial cells, SPC-A1 adenocarcinoma cells and A2780 human ovarian carcinoma cells in vitro. Compounds 2b, 3a, and 3c displayed most potent anti-proliferative activities against these tested cell strains and their anti-drug resistance effects were evaluated in vitro on cisplatin-resistant A2780 human ovarian carcinoma cells. The structure-activity relationship was also proposed. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2009.06.071

文献信息

• Semi-synthesis and anti-proliferative activity evaluation of novel analogues of Honokiol
  作者：Youfu Luo、Yongbin Xu、Lijuan Chen、Jia Hu、Cheng Peng、DaChun Xie、Jianyou Shi、Wencai Huang、Guobin Xu、Ming Peng、Jing Han、Rui Li、Shengyong Yang、Yuquan Wei

  DOI：10.1016/j.bmcl.2009.06.071

  日期：2009.8

  A series of honokiol analogues were synthesized by modifying the 5- and/or 3'-position(s) of honokiol to assess their anti-tumor effects. Some compounds exerted more potent anti-proliferative activities than those of honokiol on K562 leukemia cells, A549 alveolar basal epithelial cells, SPC-A1 adenocarcinoma cells and A2780 human ovarian carcinoma cells in vitro. Compounds 2b, 3a, and 3c displayed most potent anti-proliferative activities against these tested cell strains and their anti-drug resistance effects were evaluated in vitro on cisplatin-resistant A2780 human ovarian carcinoma cells. The structure-activity relationship was also proposed. (C) 2009 Published by Elsevier Ltd.