4-硝基苯基-2-O-(α-D-吡喃甘露糖苷)-α-D-吡喃甘露糖苷 | 16790-33-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-硝基苯基-2-O-(α-D-吡喃甘露糖苷)-α-D-吡喃甘露糖苷
• 中文别名: 4-硝基苯基2-O-(Α-D-吡喃甘露糖基)-Α-D-吡喃甘露糖苷
• 英文名称: p-nitrophenyl 2-O-α-D-mannopyranosyl-α-D-mannopyranoside
• 英文别名: (2R,3S,4S,5S,6R)-2-[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-nitrophenoxy)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 16790-33-3；41355-41-3；77856-02-1；79580-50-0；79580-51-1；83167-77-5；83167-78-6；107807-33-0；110891-72-0；124040-69-3；147103-31-9；68462-57-7
• 化学式: C₁₈H₂₅NO₁₃
• 分子量: 463.395
• InChiKey: ZGWCYKZKLZNQQX-TZXJRDDMSA-N

物化性质

• 熔点：
  153-155°C
• 沸点：
  795.6±60.0 °C(Predicted)
• 密度：
  1.70±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  224
• 氢给体数：
  7
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  对硝基苯-Alpha-D-吡喃甘露糖苷 在 α-D-galactosidase 、 sodium phosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-硝基苯基-2-O-(α-D-吡喃甘露糖苷)-α-D-吡喃甘露糖苷
  参考文献：
  名称：

  改变糖苷酶催化的二糖形成的区域选择性的简单策略。

  摘要：

  通过使用带有各种糖苷配基的α-或β-糖基受体可以改变糖苷酶催化的二糖形成的区域选择性。除了（1 ---- 6）键以外，优势糖的形成可以通过通常具有（1 ---- 6）键的糖苷酶来实现。因此，可以诱导α-D-半乳糖苷酶主要催化α-（1 ---- 2）-，α-（1 ---- 3）或α-（1 ---- 6）的形成。 ）连接的半乳​​糖苷。糖苷配基的结构和糖苷键的构型均可对二糖形成的区域选择性产生显着影响。描述了α-D-Galp-（1 ---- 3）-α-D-Galp-OMe，β-D-Galp-（1 ---- 3）的酶促合成，产率为20-30％ β-D-Galp-OMe，β-D-Galp-（1 ---- 6）-α-D-Galp-OMe，α-D-Manp-（1 ---- 2）-alpha- D-Manp-OMe，alpha-D-Manp-（1 ---- 6）-alpha-D-Manp-OMe，alpha-D-Galp-（1

  DOI：

  10.1016/0008-6215(87)80271-9

文献信息

• p-Nitrophenyl 2-, and 3-O-α-d-mannopyranosyl-α-d-mannopyranoside
  作者：Göran Ekborg、Cornelis P.J. Glaudemans

  DOI：10.1016/0008-6215(84)85024-7

  日期：1984.11

  Abstract p-Nitrophenyl 3- and 2-O-benzoyl-4,6-O-benzylidene-α- d -mannopyranoside were each condensed with 2,3,4,6-tetra-O-benzoyl-α- d -mannopyranosyl bromide, and the products were deprotected, to yield, respectively, p-nitrophenyl 2- and 3-O-α- d -mannopyranosyl-α- d -mannopyranoside.

  摘要对硝基苯基3-和2-O-苯甲酰基-4,6-O-亚苄基-α-d-甘露吡喃糖苷分别与2,3,4,6-四-O-苯甲酰基-α-d-甘露吡喃糖基溴缩合，将产物脱保护，分别得到对硝基苯基2-和3-O-α-d-甘露吡喃糖基-α-d-甘露吡喃糖苷。
• Creation of an α-Mannosynthase from a Broad Glycosidase Scaffold
  作者：Keisuke Yamamoto、Benjamin G. Davis

  DOI：10.1002/anie.201201081

  日期：2012.7.23

  α‐Mannosides made easy: Mutation of a family‐GH31 α‐glucosidase that displays plasticity to alterations at the 2‐OH position of donor substrates created an efficient α‐mannoside‐synthesizing biocatalyst. A simple fluoride donor reagent was used for the synthesis of a range of mono‐α‐mannosylated conjugates using the α‐mannosynthase displaying low (unwanted) oligomerization activity.

  α-甘露糖苷变得容易：GH31 α-葡萄糖苷酶家族的突变对供体底物的 2-OH 位置的改变显示出可塑性，创造了一种有效的 α-甘露糖苷合成生物催化剂。使用显示低（不需要的）寡聚化活性的 α-甘露糖合酶，将一种简单的氟化物供体试剂用于合成一系列单-α-甘露糖基化偶联物。
• A method of controlling the regioselectivity of glycosidic bonds
  申请人：Svenska Sockerfabriks AB

  公开号：EP0226563A1

  公开（公告）日：1987-06-24

  A method of controlling the regioselectivity of the glycosidic bond between glycosyl donor and glycosyl acceptor in the enzymatic production of an oligosaccharide compound which either consists of or is a fragment or an analog of the carbohydrate part in a glycoconjugate, by reverse hydrolysis or transglycosidation reactions, is described. The syn­thesis is carried out in that a donor substance which is a mono- or oligosaccharide or a glycoside thereof, is caused to react, in the presence of a glycosidase, with an acceptor substance which is an O-, N-, C- ­or S-glycoside consisting of a monosaccharide, oligo­saccharide or a saccharide analog and at least one aglycon which is O-, N-, C- or S-glycosidically bonded in 1-position, the α- or β-configuration being selected on the glycoside bond between the glycosyl group and the aglycon in the acceptor substance, and the oligo­saccharide compound being separated from the reaction mixture.

  本发明描述了一种在酶法生产低聚糖化合物过程中控制糖基供体和糖基受体之间糖苷键的区域选择性的方法，该低聚糖化合物由糖共轭物中碳水化合物部分的片段或类似物组成，通过反向水解或反糖苷化反应制得。合成方法是：在糖苷酶的作用下，使单糖、寡糖或其糖苷的供体物质与由单糖、寡糖或其糖苷组成的 O-、N-、C-或 S-糖苷的受体物质发生反应、寡糖或糖类似物和至少一个在 1 位上以 O-、N-、C-或 S-糖苷键结合的苷元，α-或 β-构型在受体物质中糖基和苷元之间的糖苷键上被选择，寡糖化合物从反应混合物中分离出来。
• MICROALGAE-DERIVED COMPOSITIONS FOR IMPROVING THE HEALTH AND APPEARANCE OF SKIN
  申请人：TerraVia Holdings, Inc.

  公开号：EP1986665B1

  公开（公告）日：2018-05-02
• Devices and solutions for prevention of sexually transmitted diseases
  申请人：Dillon F. Harrison

  公开号：US20070166797A1

  公开（公告）日：2007-07-19

  Provided herein are antiviral compounds and methods of culturing microalgae to produce polysaccharides. Included in the invention are methods of producing novel polysaccharides with high antiviral avtivity. Also provided are methods of using polysaccharides for applications such as preventing or treating viral infections and providing prophylaxis and treatment for sexually transmitted diseases.