trans-2-(cyclohexylamino)cyclohexan-1-ol | 52569-01-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trans-2-(cyclohexylamino)cyclohexan-1-ol
• 英文别名: 2-(cyclohexylamino)cyclohexanol；(+/-)-trans-2-Cyclohexylamino-cyclohexanol-(1)；(1S,2S)-2-(cyclohexylamino)cyclohexan-1-ol
• CAS: 52569-01-4
• 化学式: C₁₂H₂₃NO
• 分子量: 197.321
• InChiKey: TYGHMBIHLZRATP-RYUDHWBXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trans-2-(cyclohexylamino)cyclohexan-1-ol 在 tris-(dibenzylideneacetone)dipalladium(0) 、 三苯基膦 、 偶氮二甲酸二乙酯 、 2-二-叔丁膦基-2',4',6'-三异丙基联苯 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 N-cyclohexyl-2-fluoro-N-((Z)-2-fluoro-3-(naphthalen-2-yl)allyl)cyclohexan-1-amine
  参考文献：
  名称：

  钯催化氮丙啶和氮杂环丁烷与偕二氟环丙烷的氟化双官能化

  摘要：

  首次公开了通过 Pd 催化的氮丙啶和氮杂环丁烷与偕二氟环丙烷的前所未有的氟化双官能化反应，揭示了环胺的新型开环模式。

  DOI：

  10.1002/anie.202310283
• 作为产物：
  描述：

  氧化环己烯 在 乙醇 、 L-酒石酸 作用下， 生成 trans-2-(cyclohexylamino)cyclohexan-1-ol
  参考文献：
  名称：

  Mousseron; Granger, Bulletin de la Societe Chimique de France, 1947, vol. <5>, p. 850,853

  摘要：

  DOI：

文献信息

• Two-dimensional {Co3+–Zn2+} and {Co3+–Cd2+} networks and their applications in heterogeneous and solvent-free ring opening reactions
  作者：Amit Pratap Singh、Girijesh Kumar、Rajeev Gupta

  DOI：10.1039/c1dt10602c

  日期：——

  We report the synthesis and structural characterization of two-dimensional Co3+–Zn2+} and Co3+–Cd2+} heterobimetallic networks and their catalytic applications in heterogeneous and solvent-free ring opening reactions of various epoxides.

  我们报告了二维Co3+–Zn2+}和Co3+–Cd2+}异双金属网络的合成和结构表征，以及它们在各种环氧化物的异相和无溶剂开环反应中的催化应用。
• Microwave-enhanced bismuth triflate-catalyzed epoxide opening with aliphatic amines
  作者：Thierry Ollevier、Etienne Nadeau

  DOI：10.1016/j.tetlet.2007.12.100

  日期：2008.2

  In the presence of a catalytic amount of Bi(OTf)3·4H2O and under microwave irradiation, neat mixtures of epoxides and amines afforded smoothly the corresponding 2-amino alcohols. A wide variety of aliphatic amines were reacted with cycloalkene oxide, styrene oxide, and stilbene oxide. The reaction proceeded rapidly and afforded the 2-amino alcohols in high up to quantitative yields. All products could

  在催化量的Bi（OTf）3 ·4H 2 O的存在下，在微波辐射下，环氧化物和胺的纯净混合物可平稳地得到相应的2-氨基醇。使多种脂族胺与环氧化烯，氧化苯乙烯和氧化二苯乙烯反应。反应进行得很快，并以高至定量的产率得到了2-氨基醇。通过简单过滤，无需水后处理即可获得所有产品。
• Three-Dimensional {Co³⁺–Zn²⁺} and {Co³⁺–Cd²⁺} Networks Originated from Carboxylate-rich Building Blocks: Syntheses, Structures, and Heterogeneous Catalysis
  作者：Girijesh Kumar、Rajeev Gupta

  DOI：10.1021/ic400536e

  日期：2013.10.7

  The present work shows the utilization of Co3+ complexes appended with either para- or meta-arylcarboxylic acid groups as the molecular building blocks for the construction of three-dimensional Co3+-Zn2+} and Co3+-Cd2+} heterobimetallic networks. The structural characterizations of these networks show several interesting features including well-defined pores and channels. These networks function as heterogeneous and reusable catalysts for the regio- and stereoselective ring-opening reactions of various epoxides and size-selective cyanation reactions of assorted aldehydes.
• 2(1H)-Quinolinone derivatives as novel anti-arteriostenotic agents showing anti-thrombotic and anti-hyperplastic activities
  作者：Yasuo Koga、Yoshito Kihara、Minoru Okada、Yoshihiro Inoue、Shirou Tochizawa、Kazuyuki Toga、Kazue Tachibana、Yukio Kimura、Takao Nishi、Hiroyoshi Hidaka

  DOI：10.1016/s0960-894x(98)00246-7

  日期：1998.6

  In order to search for anti-arteriostenotic agents, a series of 2(1H)-quinolinone derivatives was synthesized and evaluated for anti-thrombotic activity and for anti-hyperplastic activity. From this series, (-)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido] propoxy]-2(1H)-quinolinone (1p, OPC-33509) was selected as the best candidate by balancing the efficacy on anti-thrombosis and anti-hyperplasia. (C) 1998 Elsevier Science Ltd. All rights reserved.
• 10.1002/1099-0690(200111)2001:21<4149::aid-ejoc4149<3.0.co;2-r
  作者：Curini, Massimo、Epifano, Francesco、Marcotullio, Maria Carla、Rosati, Ornelio

  DOI：10.1002/1099-0690(200111)2001:21<4149::aid-ejoc4149<3.0.co;2-r

  日期：——