1,1-dimethyl-5,8-dioxaspiro[3.4]octane-2-carbaldehyde | 1353586-67-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1-dimethyl-5,8-dioxaspiro[3.4]octane-2-carbaldehyde
• 英文别名: 1,1-Dimethyl-5,8-dioxaspiro[3.4]octane-2-carboxaldehyde；3,3-dimethyl-5,8-dioxaspiro[3.4]octane-2-carbaldehyde
• CAS: 1353586-67-0
• 化学式: C₉H₁₄O₃
• 分子量: 170.208
• InChiKey: DVISZQJFCSJFPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1-dimethyl-5,8-dioxaspiro[3.4]octane-2-carbaldehyde 在 盐酸 、 potassium carbonate 作用下， 以 甲醇 、 水 为溶剂， 反应 32.0h， 生成 3-ethynyl-2,2-dimethylcyclobutan-1-one
  参考文献：
  名称：

  Formal [4+2] cycloaddition of cyclobutanones bearing alkyne–cobalt complex at their 3-positions

  摘要：

  Cyclobutanones bearing an alkyne-cobalt complex at their 3-positions reacted with aldehydes to give formal [4+2] cycloadducts by using tin(IV) chloride as a Lewis acid. Highly substituted tetrahydropyrone derivatives were stereoselectively prepared by this method. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.067
• 作为产物：
  描述：

  2-[(benzyloxy)methyl]-1,1-dimethyl-5,8-dioxaspiro[3.4]octane 在 草酰氯 、 20 % Pd(OH)2/C 、 氢气 、 二甲基亚砜 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 2.75h， 生成 1,1-dimethyl-5,8-dioxaspiro[3.4]octane-2-carbaldehyde
  参考文献：
  名称：

  Formal [4+2] cycloaddition of cyclobutanones bearing alkyne–cobalt complex at their 3-positions

  摘要：

  Cyclobutanones bearing an alkyne-cobalt complex at their 3-positions reacted with aldehydes to give formal [4+2] cycloadducts by using tin(IV) chloride as a Lewis acid. Highly substituted tetrahydropyrone derivatives were stereoselectively prepared by this method. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.067

文献信息

• Formal [4+2] cycloaddition of cyclobutanones bearing alkyne–cobalt complex at their 3-positions
  作者：Mizuki Kawano、Takaaki Kiuchi、Jun-ichi Matsuo、Hiroyuki Ishibashi

  DOI：10.1016/j.tetlet.2011.11.067

  日期：2012.1

  Cyclobutanones bearing an alkyne-cobalt complex at their 3-positions reacted with aldehydes to give formal [4+2] cycloadducts by using tin(IV) chloride as a Lewis acid. Highly substituted tetrahydropyrone derivatives were stereoselectively prepared by this method. (C) 2011 Elsevier Ltd. All rights reserved.