(3E)-N-methyl-N-(methylsulfonyl)-2-oxo-N',4-diphenylbut-3-enimidamide | 1562381-30-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (3E)-N-methyl-N-(methylsulfonyl)-2-oxo-N',4-diphenylbut-3-enimidamide
• CAS: 1562381-30-9
• 化学式: C₁₈H₁₈N₂O₃S
• 分子量: 342.419
• InChiKey: BPNNFBUBBLBAFJ-CIVFCKLDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.89
• 重原子数：
  24.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  66.81
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  (E)-N-methyl-N-(4-phenylbut-3-en-1-yn-1-yl)methanesulfonamide 、 亚硝基苯 在 双三氟甲烷磺酰亚胺银盐 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 15.0h， 以5%的产率得到N-methyl-N-(methylsulfonyl)-N'-phenylpropiolimidamide
  参考文献：
  名称：

  Zn(II)- or Ag(I)-Catalyzed 1,4-Metathesis Reactions between 3-En-1-ynamides and Nitrosoarenes

  摘要：

  Catalyst-dependent metathesis reactions between 3-en-1-ynamides and nitrosoarenes are described. Particularly notable are the unprecedented 1,4-metathesis reactions catalyzed by Ag(I) or Zn(II) to give 2-propynimidamides and benzaldehyde derivatives. With 3-en-1-ynamides bearing a cycloalkenyl group, 1,4-oxoimination products were produced efficiently. We have developed metathesis/alkynation cascades for unsubstituted 2-propynimidamides and benzaldehyde species generated in situ, to manifest 1,4-hydroxyimination reactions of 3-en-1-ynes. Both 1,4-oxoiminations and 1,4-hydroxyiminations increase the molecular complexity of products.

  DOI：

  10.1021/ja412634w