(2R,3S,4S,5R,6R)-2-((benzoyloxy)methyl)-6-((S)-3-oxo-2-palmitamido-3-(tetradecylamino)propoxy)tetrahydro-2H-pyran-3,4,5-triyl tribenzoate | 549528-15-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R,3S,4S,5R,6R)-2-((benzoyloxy)methyl)-6-((S)-3-oxo-2-palmitamido-3-(tetradecylamino)propoxy)tetrahydro-2H-pyran-3,4,5-triyl tribenzoate
• CAS: 549528-15-6
• 化学式: C₆₇H₉₂N₂O₁₂
• 分子量: 1117.47
• InChiKey: BYADCZCWGLMCEQ-WYEGRKPJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.05
• 重原子数：
  81.0
• 可旋转键数：
  41.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  181.86
• 氢给体数：
  2.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  (2R,3S,4S,5R,6R)-2-((benzoyloxy)methyl)-6-((S)-3-oxo-2-palmitamido-3-(tetradecylamino)propoxy)tetrahydro-2H-pyran-3,4,5-triyl tribenzoate 在 甲醇 、 sodium methylate 作用下， 以100%的产率得到Hexadecanoic acid [(S)-1-tetradecylcarbamoyl-2-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-ethyl]-amide
  参考文献：
  名称：

  Design, synthesis, and evaluation of β-galactosylceramide mimics promoting β-glucocerebrosidase activity in keratinocytes

  摘要：

  We have established an efficient synthesis of mimics of beta-galactosylceramide (beta-GalCer) increasing a beta-glucocerebrosidase (beta-GlcCer'ase) activity that associates with the skin barrier function. Among the synthetic beta-GalCer analogues (6a-6e) described herein, compound 6e exhibited a potent effect on the activation of beta-GlcCer'ase function in vitro and reduced the transepidermal water loss (TEWL) level in a UVB-induced barrier disrupted mice model. These findings indicated that compound 6e could be useful for cosmetics and medicines to improve skin barrier function. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00006-4
• 作为产物：
  描述：

  beta-D-半乳糖五乙酸酯 在 palladium dihydroxide 吡啶 、 甲醇 、 N-碘代丁二酰亚胺 、 三氟甲磺酸 、 三氟化硼乙醚 、 氢气 、 sodium methylate 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 1,4-二氧六环 、 甲醇 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 生成 (2R,3S,4S,5R,6R)-2-((benzoyloxy)methyl)-6-((S)-3-oxo-2-palmitamido-3-(tetradecylamino)propoxy)tetrahydro-2H-pyran-3,4,5-triyl tribenzoate
  参考文献：
  名称：

  Design, synthesis, and evaluation of β-galactosylceramide mimics promoting β-glucocerebrosidase activity in keratinocytes

  摘要：

  We have established an efficient synthesis of mimics of beta-galactosylceramide (beta-GalCer) increasing a beta-glucocerebrosidase (beta-GlcCer'ase) activity that associates with the skin barrier function. Among the synthetic beta-GalCer analogues (6a-6e) described herein, compound 6e exhibited a potent effect on the activation of beta-GlcCer'ase function in vitro and reduced the transepidermal water loss (TEWL) level in a UVB-induced barrier disrupted mice model. These findings indicated that compound 6e could be useful for cosmetics and medicines to improve skin barrier function. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00006-4