| 1017965-00-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1017965-00-2
• 化学式: C₉H₁₄N₃O₈P
• 分子量: 323.199
• InChiKey: GFNSFKZEOXHFNW-RBXMUDONSA-N

反应信息

• 作为反应物：
  描述：

  在 叔丁基过氧化氢 、 碘 作用下， 以 四氢呋喃 、 癸烷 为溶剂， 生成 [(2R,3R,4S,5S)-3-acetyloxy-5-azido-2-phosphonooxyoxan-4-yl] acetate
  参考文献：
  名称：

  Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance

  摘要：

  Three sets of novel 4-deoxy-L-arabinose analogs were synthesized and evaluated as potential inhibitors of the bacterial resistance mechanism in which lipid A, on the outer membrane, is modified with 4-amino-4-deoxy-L-arabinose (L-Ara4N). One compound diminished the transfer of L-Ara4N onto lipid A. These results suggest that small molecules might be designed that would effect the same reversal of bacterial resistance observed in genetic knockouts. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.061