tert-butyl(4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-7-yl)-3-methylbuta-1,2-dien-1-yl)dimethylsilane | 1448195-62-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyl(4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-7-yl)-3-methylbuta-1,2-dien-1-yl)dimethylsilane
• CAS: 1448195-62-7
• 化学式: C₂₂H₄₀O₂Si
• 分子量: 364.644
• InChiKey: YAHIYSBCULGVGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.49
• 重原子数：
  25.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  tert-butyl(4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-7-yl)-3-methylbuta-1,2-dien-1-yl)dimethylsilane 在 溶剂黄146 、 sodium nitrite 作用下， 以 氯仿 为溶剂， 反应 3.0h， 以25.926%的产率得到
  参考文献：
  名称：

  Nitration of Silyl Allenes To Form Functionalized Nitroalkenes

  摘要：

  An efficient nitration of silyl allenes with nitrogen dioxide radical, generated from NaNO2 and AcOH, to form alpha-nitro-alpha,beta-unsaturated silyl oximes has been developed. A similar nitration could be achieved by using Fe(NO3)(3)center dot 9H(2)O and FeCl3 center dot 6H(2)O, but different from the regioselective oxime formation, two regioisomeric chloride-trapped products were isolated with varying ratios depending on the steric bulk of the silyl group. A novel ring-closure reaction of alpha-nitro-alpha,beta-unsaturated silyl oximes upon treating with TBAF to form isooxazolidinone derivatives was also developed.

  DOI：

  10.1021/ol401735v
• 作为产物：
  描述：

  C₂₁H₃₈O₃Si 在 四甲基乙二胺 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 tert-butyl(4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-7-yl)-3-methylbuta-1,2-dien-1-yl)dimethylsilane
  参考文献：
  名称：

  Nitration of Silyl Allenes To Form Functionalized Nitroalkenes

  摘要：

  An efficient nitration of silyl allenes with nitrogen dioxide radical, generated from NaNO2 and AcOH, to form alpha-nitro-alpha,beta-unsaturated silyl oximes has been developed. A similar nitration could be achieved by using Fe(NO3)(3)center dot 9H(2)O and FeCl3 center dot 6H(2)O, but different from the regioselective oxime formation, two regioisomeric chloride-trapped products were isolated with varying ratios depending on the steric bulk of the silyl group. A novel ring-closure reaction of alpha-nitro-alpha,beta-unsaturated silyl oximes upon treating with TBAF to form isooxazolidinone derivatives was also developed.

  DOI：

  10.1021/ol401735v