4-cyclopropyl-2-hydroxy-2-methyl-1-phenylbut-3-yn-1-one | 1046785-90-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-cyclopropyl-2-hydroxy-2-methyl-1-phenylbut-3-yn-1-one
• CAS: 1046785-90-3
• 化学式: C₁₄H₁₄O₂
• 分子量: 214.264
• InChiKey: NAGDVBUPFROMCS-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  4-cyclopropyl-2-hydroxy-2-methyl-1-phenylbut-3-yn-1-one 在 platinum(II) chloride 作用下， 以 甲苯 为溶剂， 反应 3.0h， 生成 5-cyclopropyl-2-methyl-2-phenylfuran-3(2H)-one 、 (E)-4-cyclopropyl-2-methyl-1-phenylbut-2-ene-1,4-dione
  参考文献：
  名称：

  Pt-catalyzed cyclization/migration of propargylic alcohols for the synthesis of 3(2H)-furanones, pyrrolones, indolizines, and indolizinones

  摘要：

  Several heterocycles such as furanones, pyrrolones, and indolizines, which are of pharmacological importance, are easily accessed via the Pt(II)-catalyzed heterocyclization/1,2-migration of propargylic ketols or hydroxy imine derivatives. This method sidesteps the challenges of traditional heteroaromatic oxygenation strategies such as regioselectivity and functional group tolerance in the syntheses of these heterocycles. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.103
• 作为产物：
  描述：

  在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 以23%的产率得到4-cyclopropyl-2-hydroxy-2-methyl-1-phenylbut-3-yn-1-one
  参考文献：
  名称：

  Pt-catalyzed cyclization/migration of propargylic alcohols for the synthesis of 3(2H)-furanones, pyrrolones, indolizines, and indolizinones

  摘要：

  Several heterocycles such as furanones, pyrrolones, and indolizines, which are of pharmacological importance, are easily accessed via the Pt(II)-catalyzed heterocyclization/1,2-migration of propargylic ketols or hydroxy imine derivatives. This method sidesteps the challenges of traditional heteroaromatic oxygenation strategies such as regioselectivity and functional group tolerance in the syntheses of these heterocycles. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.103