4-(quinolin-8-yloxy)butanohydrazide | 927421-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(quinolin-8-yloxy)butanohydrazide
• 英文别名: 4-Quinolin-8-yloxybutanehydrazide
• CAS: 927421-66-7
• 化学式: C₁₃H₁₅N₃O₂
• 分子量: 245.281
• InChiKey: FQRSRVCCPRACBF-UHFFFAOYSA-N

物化性质

• 沸点：
  525.3±30.0 °C(Predicted)
• 密度：
  1.226±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  77.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(quinolin-8-yloxy)butanohydrazide 、 2-羟基-3,5-二甲基-苯甲醛 以 乙醇 为溶剂， 反应 3.0h， 以50%的产率得到
  参考文献：
  名称：

  Shen, Hongfang; Lu, Youjun; Gen, Guihong, Asian Journal of Chemistry, 2012, vol. 24, # 4, p. 1847 - 1850

  摘要：

  DOI：

文献信息

• A Flexible Spacer Schiff-Base (<i>E</i>)-<i>N</i>’-(5-bromo-2-hydroxybenzylidene)-4-(quinolin-8-yloxy)butanehydrazide Synthesis, Crystal Structure, and Fluorescence
  作者：Zhigang Wen、Jiaming Li

  DOI：10.1080/15533174.2011.568438

  日期：2011.5.1

  A new Schiff base compound, (E)-N'-(5-bromo-2-hydroxy- benzylidene)-4-(quinolin-8-yloxy)butanehydrazide, 1, was synthesized and characterized by elemental analysis, IR spectrum, 1HNMR, and single crystal X-ray diffraction. The asymmetric unit of 1 contains two crystallographic independent molecules with different conformations along the bond sequence linking the benzene and quinoline rings, which have a mean interplanar dihedral angle of 58.9(6) and 10.2(6)degrees, respectively. In the crystal, the molecules are linked through hydrogen bonds of N-H...O and C-H...O to form an infinite 1-D chain, which is further extended to a supramolecular 3-D network via Br...Br and ... interactions. The fluorescence property of the compound 1 was investigated.
• Synthesis, Characterization, Crystal Structure, and Fluorescence Properties of a Schiff Base Containing Aliphatic Spacers
  作者：Li Zeng、Chunyan Fu、Lihua Lv、Gengxi Li、Qi Zhu

  DOI：10.1080/15533174.2011.591870

  日期：2011.10.1

  Crystals of the Schiff base compound C22H24N4O4, 1, was obtained by the reaction of indole-3-carbaldehyde with 4-(quinolin-8-yloxy)butanohydrazide and recrystallization of the product from dimethylformamide. The compound 1 has been characterized by elemental analysis, infrared (IR), H-1-nuclear magnetic resonance (NMR), fluorescence (FL) spectra, and x-ray single crystal and powder x-ray diffraction measurements. The conformation along the bond sequence linking the indole and quinoline rings, which have a mean interplanar dihedral angle of 80.9 (4)degrees, is trans-trans-(-)gauche-trans-trans-trans-trans. In the crystal structure, the intermolecular N-H center dot center dot center dot N hydrogen bond links the molecules into a zigzag one-dimensional (1-D) infinite chain structure. These chains are further aggregated via pi center dot center dot center dot pi interactions into parallel layers, resulting in a supramolecular two-dimensional fragment.
• Shen, Hongfang; Lu, Youjun; Gen, Guihong, Asian Journal of Chemistry, 2012, vol. 24, # 4, p. 1847 - 1850
  作者：Shen, Hongfang、Lu, Youjun、Gen, Guihong、Zhang, Shengsen

  DOI：——

  日期：——