N-(2-(diethylamino)ethyl)-3-chloroacridine-4-carboxamide | 1070308-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(2-(diethylamino)ethyl)-3-chloroacridine-4-carboxamide
• CAS: 1070308-24-5
• 化学式: C₂₀H₂₂ClN₃O
• 分子量: 355.867
• InChiKey: XQVMINJKLIAOTK-UHFFFAOYSA-N

物化性质

• 熔点：
  229-231 °C
• 沸点：
  552.6±35.0 °C(predicted)
• 密度：
  1.214±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  N,N-二乙基乙二胺 、 3-chloroacridine-4-carbonyl chloride 在 三甲基铝 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 N-(2-(diethylamino)ethyl)-3-chloroacridine-4-carboxamide
  参考文献：
  名称：

  Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma

  摘要：

  Various iodo-acridone and acridine carboxamides have been prepared and evaluated as agents for targeted radionuclide and/or chemotherapy for melanoma, due to their structural similarity to benzamides which are known to possess specific affinity for melanin. Three of these carboxamides selected for their in vitro cytotoxic properties were radioiodinated with [I-125] NaI at high specific activity. Biodistribution studies carried out in B16F0 murine melanoma tumour-bearing mice highlighted that acridone 8f and acridine 9d, presented high, long-lasting tumour concentrations together with an in vivo kinetic pro. le favourable to application in targeted radionuclide therapy. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.07.015