Trimethyl(2-pyridin-3-yloxyethyl)azanium;chloride | 496967-65-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Trimethyl(2-pyridin-3-yloxyethyl)azanium;chloride
• CAS: 496967-65-8
• 化学式: C₁₀H₁₇N₂O*Cl
• 分子量: 216.711
• InChiKey: MESGABZZIAYUOF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.83
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-1-(吡啶-3-氧基)乙烷 、 三甲胺 以51%的产率得到Trimethyl(2-pyridin-3-yloxyethyl)azanium;chloride
  参考文献：
  名称：

  Quaternary ammonium 3-(aminoethoxy)pyridines as antinociceptive agents

  摘要：

  Quaternization via N-methylation of the terminal amines of a series of 3-(dialkylaminoethoxy)pyridines resulted in analogues that displayed up to 50-60-fold enhanced affinity for nicotinic acetylcholinergic (nACh) receptors. Several of these compounds displayed antinociceptive properties in mice using the tail-flick assay and serve as possible leads for the development of novel analgesic agents. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00585-7

文献信息

• Quaternary ammonium 3-(aminoethoxy)pyridines as antinociceptive agents
  作者：Rahime Simsek、Jean Chang-Fong、Mase Lee、Malgorzata Dukat、M. Imad Damaj、Billy R. Martin、Richard A. Glennon

  DOI：10.1016/s0960-894x(03)00585-7

  日期：2003.9

  Quaternization via N-methylation of the terminal amines of a series of 3-(dialkylaminoethoxy)pyridines resulted in analogues that displayed up to 50-60-fold enhanced affinity for nicotinic acetylcholinergic (nACh) receptors. Several of these compounds displayed antinociceptive properties in mice using the tail-flick assay and serve as possible leads for the development of novel analgesic agents. (C) 2003 Elsevier Ltd. All rights reserved.