(2R,3S,4R)-7,7-dimethoxy-3-(4-methoxybenzyloxy)-2,4-dimethylheptan-1-ol | 881652-76-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R,3S,4R)-7,7-dimethoxy-3-(4-methoxybenzyloxy)-2,4-dimethylheptan-1-ol
• 英文别名: (2R,3S,4R)-7,7-dimethoxy-3-[(4-methoxyphenyl)methoxy]-2,4-dimethylheptan-1-ol
• CAS: 881652-76-2
• 化学式: C₁₉H₃₂O₅
• 分子量: 340.46
• InChiKey: XGCHTHWRUOVURT-CLCXKQKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2R,3S,4R)-7,7-dimethoxy-3-(4-methoxybenzyloxy)-2,4-dimethylheptan-1-ol 在 sodium chlorite 、 disodium hydrogenphosphate 、 2-甲基-2-丁烯 、 草酰氯 、 potassium carbonate 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 、 丙酮 、 叔丁醇 为溶剂， 反应 3.0h， 生成 (2S,3S,4R)-allyl 7,7-dimethoxy-3-(4-methoxybenzyloxy)-2,4-dimethylheptanoate
  参考文献：
  名称：

  Total Synthesis of Dolabelide D

  摘要：

  The first total synthesis of dolabelide D (or of any of the closely related dolabelides) has been achieved with a longest linear sequence of 17 steps. Key features of the synthesis include an application of the catalytic asymmetric silane alcoholysis, the tandem silylformylation-crotylsilylation, and a Brook-like 1,4-carbon to oxygen silyl migration.

  DOI：

  10.1021/ja058692k
• 作为产物：
  描述：

  1-(((3S,4R)-7,7-dimethoxy-2,4-dimethylhept-1-en-3-yloxy)methyl)-4-methoxybenzene 在 9-borabicyclo[3.3.1]nonane dimer 、 sodium hydroxide 、 双氧水 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 生成 (2R,3S,4R)-7,7-dimethoxy-3-(4-methoxybenzyloxy)-2,4-dimethylheptan-1-ol
  参考文献：
  名称：

  Total Synthesis of Dolabelide D

  摘要：

  The first total synthesis of dolabelide D (or of any of the closely related dolabelides) has been achieved with a longest linear sequence of 17 steps. Key features of the synthesis include an application of the catalytic asymmetric silane alcoholysis, the tandem silylformylation-crotylsilylation, and a Brook-like 1,4-carbon to oxygen silyl migration.

  DOI：

  10.1021/ja058692k

文献信息

• Total Synthesis of Dolabelide D
  作者：Peter K. Park、Steven J. O'Malley、Darby R. Schmidt、James L. Leighton

  DOI：10.1021/ja058692k

  日期：2006.3.1

  The first total synthesis of dolabelide D (or of any of the closely related dolabelides) has been achieved with a longest linear sequence of 17 steps. Key features of the synthesis include an application of the catalytic asymmetric silane alcoholysis, the tandem silylformylation-crotylsilylation, and a Brook-like 1,4-carbon to oxygen silyl migration.