4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-2-carboxylic acid | 1233334-74-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-2-carboxylic acid
• 英文别名: 7,7-dimethyl-5-oxo-4-(4-methoxyphenyl)-1,4,5,6,7,8-hexahydro-2-quinolinecarboxylic acid；4-(4-Methoxyphenyl)-7,7-dimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-2-carboxylic acid
• CAS: 1233334-74-1
• 化学式: C₁₉H₂₁NO₄
• 分子量: 327.38
• InChiKey: PNIVEJQHRBNMFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ethyl 4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-2-carboxylate 在 乙醇 、 sodium carbonate 作用下， 以92.8%的产率得到4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-2-carboxylic acid
  参考文献：
  名称：

  Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents

  摘要：

  A series of 2,4-disubstituted polyhydroquinoline were synthesized and evaluated for their in vivo antihyperglycemic as well as antidyslipidemic activities. Several synthesized compounds have exhibited promising in vivo antihyperglycemic in SLM, STZ-S, and db/db mice model along with significant lipid and TG modulating activity. All these compounds were evaluated in various in vitro models of diabetes to know the possible mechanism of their antihyperglycemic action. Interestingly, compounds 3a-r (diaryl substitution) have exhibited promising protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity whereas, compounds 5a-d (acid substituted) have shown significant glycogen phosphorylase activity. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2009.11.061

文献信息

• TiO₂ -SiO₂ nanocomposite-promoted efficient cyclocondensation reaction of arylmethylidenepyruvic acids with dimedone in aqueous media
  作者：Sepehr Sadegh-Samiei、Shahrzad Abdolmohammadi

  DOI：10.1002/jccs.201800057

  日期：2018.10

  8‐hexahydro‐2‐quinolinecarboxylic acids through a condensation reaction of arylmethylidenepyruvic acids with ammonium acetate and dimedone using a catalytic amount of TiO2–SiO2 nanocomposite (15 mol%) at room temperature in aqueous media. The principal advantage of this procedure is the relatively high yields (94–98%) with short reaction times (2 hr), under mild reaction conditions and with low environmental impact

  这项工作的重点是通过芳基亚甲基亚丙酮酸与乙酸铵的缩合反应成功合成4-芳基-7,7-二甲基-5-氧代-1,4,5,6,7,8-六氢-2-喹啉羧酸在室温下，在水性介质中，使用催化量的TiO 2 -SiO 2纳米复合材料（15摩尔％）和二甲酮。该方法的主要优点是在较短的反应时间（2小时），温和的反应条件下，对环境的影响较小的情况下，产率较高（94-98％）。
• TiO2 nanoparticles as an effective catalyst for the synthesis of hexahydro-2-quinolinecarboxylic acids derivatives
  作者：Shahrzad Abdolmohammadi

  DOI：10.1016/j.cclet.2012.06.038

  日期：2012.9

  The one-pot three-component reaction of arylmethylidenepyruvic acids, 1,3-cyclohexandiones and ammonium acetate provides an economical and efficient synthetic route to 5-oxo-4-aryl-1,4,5,6,7,8-hexahydro-2-quinolinecarboxylic acid 4 under solvent-free conditions using a catalytic amount of TiO2 nanoparticles (TiO2 NPs) as an effective heterogeneous catalyst. (C) 2012 Shahrzad Abdolmohammad. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
• Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents
  作者：Atul Kumar、Siddharth Sharma、Vishwa Deepak Tripathi、Ram Awatar Maurya、Swayam Prakash Srivastava、Gitika Bhatia、A.K. Tamrakar、Arvind Kumar Srivastava

  DOI：10.1016/j.bmc.2009.11.061

  日期：2010.6.1

  A series of 2,4-disubstituted polyhydroquinoline were synthesized and evaluated for their in vivo antihyperglycemic as well as antidyslipidemic activities. Several synthesized compounds have exhibited promising in vivo antihyperglycemic in SLM, STZ-S, and db/db mice model along with significant lipid and TG modulating activity. All these compounds were evaluated in various in vitro models of diabetes to know the possible mechanism of their antihyperglycemic action. Interestingly, compounds 3a-r (diaryl substitution) have exhibited promising protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity whereas, compounds 5a-d (acid substituted) have shown significant glycogen phosphorylase activity. (C) 2009 Published by Elsevier Ltd.