[4-(Aminomethyl)cyclohexyl]methanol | 17879-23-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [4-(Aminomethyl)cyclohexyl]methanol
• 英文别名: [trans-4-(aminomethyl)cyclohexyl]methanol；trans-[4-(aminomethyl)cyclohexyl]methanol；trans-4-(aminomethyl)cyclohexanemethanol
• CAS: 17879-23-1
• 化学式: C₈H₁₇NO
• 分子量: 143.229
• InChiKey: WWDKVICMJWBJKJ-ZKCHVHJHSA-N

物化性质

• 沸点：
  243.4±13.0 °C(Predicted)
• 密度：
  0.956±0.06 g/cm3(Predicted)
• 溶解度：
  氯仿（微溶）、DMSO（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  0.74
• 重原子数：
  10.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.25
• 氢给体数：
  2.0
• 氢受体数：
  2.0

安全信息

• 包装等级：
  III
• 危险类别：
  8
• 危险性防范说明：
  P260,P264,P280,P301+P310+P330+P331,P303+P361+P353+P310,P304+P340+P310,P305+P351+P338+P310,P363,P405,P501
• 危险品运输编号：
  3259
• 危险性描述：
  H314

反应信息

• 作为反应物：
  描述：

  [4-(Aminomethyl)cyclohexyl]methanol 在 偶氮二甲酸二异丙酯 、 sodium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 9-[trans-4-(N-benzyloxycarbonylaminomethyl)cyclohexylmethyl]adenine
  参考文献：
  名称：

  Progesterone–adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux: Design, synthesis, characterization and biological evaluation

  摘要：

  Bivalent ligands were designed on the basis of the described close proximity of the ATP-site and the putative steroid-binding site of P-glycoprotein (ABCB1). The syntheses of 19 progesterone-adenine hybrids are described. Their abilities to inhibit P-glycoprotein-mediated daunorubicin efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein were evaluated versus progesterone. The hybrid with a hexamethylene linker chain showed the best inhibitory potency. The efficiency of these progesterone-adenine hybrids depends on two main factors: (i) the nature of the linker and (ii) its attachment point on the steroid skeleton. (C) 2012 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.steroids.2012.07.010
• 作为产物：
  描述：

  tranexamic acid 在 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 为溶剂， 生成 [4-(Aminomethyl)cyclohexyl]methanol
  参考文献：
  名称：

  AROMATIC AMINE AR AND BET TARGETING PROTEIN DEGRADATION CHIMERA COMPOUND AND USE

  摘要：

  一种芳香胺雄激素受体（AR）和BET靶向蛋白降解嵌合物化合物及其用途。具体提供的是由式I表示的化合物。实验结果表明，该化合物可以靶向降解AR和BRD4，并下调AR和BRD4蛋白的表达；该化合物可以抑制多种前列腺癌细胞的增殖；该化合物可以抑制过表达AR的前列腺癌细胞系LNCaP/AR的增殖，并且对一种对市售前列腺癌药物（恩扎鲁胺）具有耐药性的前列腺癌细胞系22RV1具有良好的抑制效果；该化合物还表现出良好的代谢稳定性，在制备AR和/或BET蛋白降解靶向嵌合物和治疗由AR和BET调控的相关疾病的药物方面具有良好的应用前景。

  公开号：

  EP3971176A1

文献信息

• [EN] BROAD-SPECTRUM CARBAPENEMS<br/>[FR] CARBAPÉNÈMES À LARGE SPECTRE
  申请人：VENATORX PHARMACEUTICALS INC

  公开号：WO2019232053A1

  公开（公告）日：2019-12-05

  The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.

  本公开提供广谱碳青霉烯衍生物及用于治疗细菌感染的药物组合物，以及使用这些衍生物和/或组合物治疗感染的方法。
• Urea substituted benzothiazoles
  申请人：——

  公开号：US20040242576A1

  公开（公告）日：2004-12-02

  The present invention relates to compounds of formula I 1 wherein R 1 and R 2 are described herein, and their pharmaceutically acceptable salts thereof for the treatment of diseases, related to the A 2A receptor.

  本发明涉及式I1的化合物，其中R1和R2如本文所述，并且它们的药用可接受盐，用于治疗与A2A受体相关的疾病。
• Thermoplastic polyester molding compositions
  申请人：Eastman Kodak Company

  公开号：US04420581A1

  公开（公告）日：1983-12-13

  This invention concerns thermoplastic polyester molding compositions containing iron oxides, particularly Fe.sub.2 O.sub.3 which compositions exhibit markedly reduced heat up times and are especially useful in molding operations such as blow molding of beverage bottles. The polyester polymer may have incorporated therein by copolymerization certain anthraquinone dyes having functional groups which condense during polymerization into the polyester chain. The dye moieties are thermally stable at the polymer processing temperatures and are colorfast and non-extractable from the polymer.

  本发明涉及热塑性聚酯模塑组合物，其中包含铁氧化物，特别是Fe.sub.2 O.sub.3，这些组合物表现出明显降低的加热时间，并且在模塑操作中特别有用，例如吹塑饮料瓶。聚酯聚合物可以通过共聚合反应将某些蒽醌染料含有的官能团引入聚酯链中。染料基团在聚合物加工温度下具有热稳定性，并且色牢度好，不会从聚合物中溶出。
• Polyester polymers containing residues of anthroquinone dyes
  申请人：Eastman Kodak Company

  公开号：US04267306A1

  公开（公告）日：1981-05-12

  Disclosed are anthraquinone dyes useful in conventional dyeing of synthetic fibers and for incorporation by copolymerization into polyesters for coloring the same, said dyes having the structure ##STR1## wherein R is --OH, --COOR.sup.1, or --COX wherein R.sup.1 is --H or a radical such as lower alkyl which may be used in polyester forming condensation reactions, X is halogen, preferably Cl or Br, n is 1 or 2, either A or B of II must contain, and A or B of I may contain, at least one additional ##STR2## group, and each of rings A and B may be substituted with 1-3 radicals such as lower alkyl, cycloalkyl, lower alkoxy, chlorine, bromine, amino, lower alkyl amino, substituted lower alkyl amino, aryl amino, lower alkylsulfonyl, lower alkylthio, arylthio, and the like. The term "lower " as used herein means 1-6 carbons. These dyes can be used for conventional dyeing of a variety of fibers including polyester, polyamide, and cellulose ester, in addition to dyeing polymers by incorporation into the molecule, and are particularly useful for imparting red to greenish-blue shades to polyester plastics materials such as bottles when employed in the proper combinations.

  本发明涉及一种蒽醌染料，可用于合成纤维的传统染色，也可通过共聚合并入聚酯中进行着色。该染料的结构为：##STR1## 其中R为—OH，—COOR.sup.1或—COX，其中R.sup.1为—H或类似较低烷基的基团，可用于聚酯形成缩合反应，X为卤素，优选为Cl或Br，n为1或2，II中的A或B必须包含，并且I中的A或B可以包含至少一个额外的##STR2##基团，环A和B中的每一个都可以用1-3个较低烷基，环烷基，较低烷氧基，氯，溴，氨基，较低烷基氨基，取代较低烷基氨基，芳基氨基，较低烷基磺酰基，较低烷基硫醇基，芳基硫醇基等基团进行取代。在本文中，“较低”一词的含义是1-6个碳原子。这些染料可用于各种纤维的传统染色，包括聚酯，聚酰胺和纤维素酯，此外还可通过将其并入分子中对聚合物进行染色，特别适用于在适当的组合下赋予聚酯塑料材料（如瓶子）红色到绿蓝色调。
• Pyrimidine Derivatives Useful as Inhibitors of Pkc-Theta
  申请人：Barbosa Antonio J.M.

  公开号：US20080318929A1

  公开（公告）日：2008-12-25

  Disclosed are novel compounds of formula (I) wherein R 1 , R 2 , R 3 , and R 4 and A are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

  本发明涉及一种新型化合物，其化学式为(I)，其中R1、R2、R3、R4和A的定义如本文所述，这些化合物可用作PKC-theta的抑制剂，因此可用于治疗通过PKC-theta的活性介导或维持的多种疾病和障碍，包括免疫性疾病和2型糖尿病。本发明还涉及包含这些化合物的制药组合物、使用这些化合物治疗各种疾病和障碍的方法、制备这些化合物的过程以及在这些过程中有用的中间体。