(2-acetamido-3,4-di-O-benzyl-2-deoxy-6-O-sulfo-α-D-glucopyranosyl)-(1->4)-[(2,3-di-O-benzyl-1,5-dideoxy-1,5-imino-N-(4-nitro)benzenesulfonyl-L-iditol)uronic acid] | 1252259-02-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-acetamido-3,4-di-O-benzyl-2-deoxy-6-O-sulfo-α-D-glucopyranosyl)-(1->4)-[(2,3-di-O-benzyl-1,5-dideoxy-1,5-imino-N-(4-nitro)benzenesulfonyl-L-iditol)uronic acid]
• CAS: 1252259-02-1
• 化学式: C₄₈H₅₁N₃O₁₇S₂
• 分子量: 1006.07
• InChiKey: HBGWSVGPYTTZQG-MBOFPEJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.83
• 重原子数：
  70.0
• 可旋转键数：
  22.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  265.9
• 氢给体数：
  3.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  (2-acetamido-3,4-di-O-benzyl-2-deoxy-6-O-sulfo-α-D-glucopyranosyl)-(1->4)-[(2,3-di-O-benzyl-1,5-dideoxy-1,5-imino-N-(4-nitro)benzenesulfonyl-L-iditol)uronic acid] 在 苯硫酚 、 三乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以73%的产率得到
  参考文献：
  名称：

  Synthesis of glycosaminoglycan oligosaccharides. Part 4: Synthesis of aza-l-iduronic acid-containing analogs of heparan sulfate oligosaccharides as heparanase inhibitors

  摘要：

  The synthesis of three azasugar-containing analogs of the disaccharide units of heparan sulfate, which are potential inhibitors of the enzyme heparanase, is reported. Synthetic routes were developed for the preparation of L-ido-nojirimycin type glycosyl acceptors with O-4 free. Glycosylation of these acceptors with an O-6 functionalized 2-azido-2-deoxy-n-glucose thioglycoside donor afforded the a-linked disaccharides in good yields. The advantages of using the 4-nitrobenzenesulfonyl group for the protection of the ring nitrogen of azasugars were demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.07.055
• 作为产物：
  描述：

  (2-acetamido-3,4-di-O-benzyl-2-deoxy-α-D-glucopyranosyl)-(1->4)-[tert-butyl (2,3-di-O-benzyl-1,5-dideoxy-1,5-imino-N-(4-nitro)benzenesulfonyl-L-iditol)uronate] 在 三氟乙酸 、 三氧化硫吡啶 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.17h， 以94%的产率得到(2-acetamido-3,4-di-O-benzyl-2-deoxy-6-O-sulfo-α-D-glucopyranosyl)-(1->4)-[(2,3-di-O-benzyl-1,5-dideoxy-1,5-imino-N-(4-nitro)benzenesulfonyl-L-iditol)uronic acid]
  参考文献：
  名称：

  Synthesis of glycosaminoglycan oligosaccharides. Part 4: Synthesis of aza-l-iduronic acid-containing analogs of heparan sulfate oligosaccharides as heparanase inhibitors

  摘要：

  The synthesis of three azasugar-containing analogs of the disaccharide units of heparan sulfate, which are potential inhibitors of the enzyme heparanase, is reported. Synthetic routes were developed for the preparation of L-ido-nojirimycin type glycosyl acceptors with O-4 free. Glycosylation of these acceptors with an O-6 functionalized 2-azido-2-deoxy-n-glucose thioglycoside donor afforded the a-linked disaccharides in good yields. The advantages of using the 4-nitrobenzenesulfonyl group for the protection of the ring nitrogen of azasugars were demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.07.055