| 1004315-57-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1004315-57-4
• 化学式: C₃₁H₄₅NO₂₀
• 分子量: 751.693
• InChiKey: MJYOFYYMHKXWDE-LVLLTTCXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.49
• 重原子数：
  52.0
• 可旋转键数：
  16.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  273.34
• 氢给体数：
  1.0
• 氢受体数：
  21.0

反应信息

• 作为反应物：
  描述：

  、 辛二酸 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 36.0h， 以83%的产率得到N-{2-[1,3-di(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)]propanyl}octane-1,8-diamide
  参考文献：
  名称：

  Design and synthesis of novel multivalent mannosides targeting the mannose receptor

  摘要：

  According to the characteristics of C-type lectin-like domains in the mannose receptor (MR), a novel design of multivalent mannosides targeting the MR was accomplished. Beginning with a divalent mannoside as the sugar unit, a series of multivalent mannosides with variations in both valence and space were synthesized in a convergent approach. The synthetic multivalent mannosides are to be explored to study MR-sugar binding events. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2007.08.017
• 作为产物：
  描述：

  2-azido-1,3-di-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)propane 在 palladium dihydroxide 氢气 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 20.0 ℃ 、400.01 kPa 条件下， 反应 3.0h， 生成
  参考文献：
  名称：

  Design and synthesis of novel multivalent mannosides targeting the mannose receptor

  摘要：

  According to the characteristics of C-type lectin-like domains in the mannose receptor (MR), a novel design of multivalent mannosides targeting the MR was accomplished. Beginning with a divalent mannoside as the sugar unit, a series of multivalent mannosides with variations in both valence and space were synthesized in a convergent approach. The synthetic multivalent mannosides are to be explored to study MR-sugar binding events. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2007.08.017

文献信息

• Synthesis of a series of novel heteroglycoclusters and homoglycoclusters and the study of their anti-adhesion activities
  作者：Shan Jiang、Shan Niu、Zhi-Hui Zhao、Zhong-Jun Li、Qing Li

  DOI：10.1016/j.carres.2015.06.002

  日期：2015.9

  A new series of mixed-type heteroglycoclusters containing mannose and lactose were synthesized. In the synthesis of rigid scaffold of heteroglycocluster, we found that trans-isomer could be prepared stereoselectively by means of Grubbs olefin cross-metathesis reactions. Moreover, sequential acylation using cyclic anhydride as scaffold could give cis-isomer. These two methods may provide complementarity

  合成了一系列新的包含甘露糖和乳糖的混合型杂糖簇。在杂糖簇的刚性支架的合成中，我们发现可以通过Grubbs烯烃交叉复分解反应立体选择性地制备反式异构体。此外，使用环酐作为支架的顺序酰化可以得到顺式异构体。这两种方法可以在异糖簇组装中提供立体化学的互补性。这些化合物的抗黏附活性通过表面等离子体共振（SPR）和基于静态细胞的黏附测定进行评估。这些结果表明刚性支架可能不会影响抗粘连活性。
• Synthesis of a series of new glycoclusters and the evaluation of their anti-adhesion activities
  作者：Xiaorong Zhang、Aqin Liu、Zhihui Zhao、Zhongjun Li、Qing Li

  DOI：10.1016/j.carres.2017.08.013

  日期：2017.10

  cellose and lactose residues showed good anti-adhesion activity of leukocytes to endothelial cells and exerted anti-inflammatory effects. Based on these results and combination principles of drugs, a series of new glycoclusters modifying with potentially anti-oxidant activity pharmacophores have been synthesized, and their anti-adhesion activities were assessed by static state cell-based adhesion assay

  根据我们的早期研究，一些具有葡萄糖，甘露糖，纤维素和乳糖残基的糖团显示出良好的白细胞对内皮细胞的抗粘附活性，并发挥了抗炎作用。基于这些结果和药物的组合原理，已合成了一系列用潜在的抗氧化活性药效团修饰的新糖簇，并通过基于静态细胞的粘附测定法评估了它们的抗粘附活性。结果表明，某些修饰的糖簇显示出比其先导化合物更好的活性。