4-苯基-1,2,5-恶二唑-3-胺 | 10349-14-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-苯基-1,2,5-恶二唑-3-胺
• 英文名称: 4-phenyl-furazan-3-ylamine
• 英文别名: 3-amino-4-phenylfurazan；4-phenyl-1,2,5-oxadiazol-3-amine；3-amino-4-phenyl-1,2,5-oxadiazole
• CAS: 10349-14-1
• 化学式: C₈H₇N₃O
• mdl: MFCD00124949
• 分子量: 161.163
• InChiKey: APGIIVSHRRCAPU-UHFFFAOYSA-N

物化性质

• 熔点：
  99 °C
• 沸点：
  313.9±34.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.9
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  4-苯基-1,2,5-恶二唑-3-胺 以 四氢呋喃 为溶剂， 生成 N-phenyl-N'-(4-phenyl-furazan-3-yl)-formamidine
  参考文献：
  名称：

  Ruccia,M. et al., Journal of the Chemical Society. Perkin transactions I, 1977, p. 589 - 591

  摘要：

  DOI：
• 作为产物：
  描述：

  2-hydroxyimino-2-phenyl-acetohydroximoyl chloride 在 ammonium hydroxide 、 sodium hydroxide 、 乙醚 、 乙醇 、 sodium acetate 作用下， 生成 4-苯基-1,2,5-恶二唑-3-胺
  参考文献：
  名称：

  Ponzio, Gazzetta Chimica Italiana, 1930, vol. 60, p. 886,890

  摘要：

  DOI：

文献信息

• Aminofuroxane. 1. Synthese und Struktur
  作者：Andr� R. Gagneux、Ren� Meier

  DOI：10.1002/hlca.19700530738

  日期：——

  Phenylglyoximes are transformed in a single operation into 3-amino-4-phenyl-furoxans which rearrange quantitatively to their 3-phenyl-4-amino-isomers above 80°. A mechanism for the synthesis is proposed and supported by the isolation of intermediates. Proof for the structure of both furoxan isomers and intermediate phenylaminoglyoximes rests on chemical transformations, mechanistic considerations,

  苯乙二肟在一次操作中即可转化为3-氨基-4-苯基-呋喃喃酮，后者可在80°以上定量重新排列为它们的3-苯基-4-氨基-异构体。提出了一种合成机制，并由中间体的分离提供了支持。呋喃烷异构体和中间体苯基氨基乙二肟的结构证明均取决于化学转化，机理考虑因素以及某些结构变化对UV-光谱的影响。
• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20020045747A1

  公开（公告）日：2002-04-18

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性治疗阿尔茨海默病的方法。
• DIKETO-PIPERAZINE AND PIPERIDINE DERIVATIVES AS ANTIVIRAL AGENTS
  申请人：Wang Tao

  公开号：US20070249579A1

  公开（公告）日：2007-10-25

  This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with diketo piperazine and piperadine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.

  本公开提供具有药物和生物影响特性的化合物，它们的药物组合物和使用方法。具体而言，该公开涉及具有独特抗病毒活性的二酮哌嗪和哌啶衍生物。更具体地说，本公开涉及用于治疗艾滋病毒和艾滋病的化合物。
• Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Athena Neurosciences, Inc.

  公开号：US06506782B1

  公开（公告）日：2003-01-14

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
• Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Elan Pharmaceuticals, Inc.

  公开号：US06509331B1

  公开（公告）日：2003-01-21

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。