cis-2,6-dibromocyclohexanone | 16080-75-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cis-2,6-dibromocyclohexanone
• 英文别名: cis-2,6-dibromo-cyclohexanone；cis-2,6-Dibrom-cyclohexanon；cis-2.6-Dibrom-cyclohexanon-(1)；cis-2,6-Dibrom-cyclohexan-1-on；cis-2,6-Dibrom-cyclohexanon；cis-2,6-Dibromcyclohexanon；(2S,6R)-2,6-dibromocyclohexan-1-one
• CAS: 16080-75-4
• 化学式: C₆H₈Br₂O
• 分子量: 255.937
• InChiKey: MDHTXSRMTCJEBR-SYDPRGILSA-N

物化性质

• 熔点：
  111-112 °C
• 沸点：
  263.1±40.0 °C(Predicted)
• 密度：
  1.943±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  sodium benzoate 、 cis-2,6-dibromocyclohexanone 以 二乙二醇二甲醚 为溶剂， 生成 2-benzoyloxy-cyclohex-2-en-1-one
  参考文献：
  名称：

  1,3-Elimination-Rearrangement of 2-Acetoxy-6-bromocyclohexanones

  摘要：

  DOI：

  10.1021/jo01340a001
• 作为产物：
  描述：

  环己酮 在 1,4-二氧六环 、 乙醚 、 溴 作用下， 生成 cis-2,6-dibromocyclohexanone
  参考文献：
  名称：

  Matschinskaja; Podberesina, Zhurnal Obshchei Khimii, 1958, vol. 28, p. 1501; engl. Ausg. S. 1550

  摘要：

  DOI：

文献信息

• Dichotomous Reactivity of PCl₅and PBr₅Toward Cyclic Ketones: A One-Step Preparation of 1,1,2-Trichlorocycloalkanes
  作者：Alan B. Brown、Chris W. Chronister、Diana M. Watkins、Richard J. Mazzaccaro、Scott R. Rajski、Martha G. Fountain、Scott E. McKay、Tracy L. Gibson

  DOI：10.1080/00397919508011382

  日期：1995.2

  Abstract Small-ring cyclic ketones react with excess PCl5 in CCl4 (reflux, 1-3 d) to give the corresponding 1,1,2-trichlorocycloalkanes, but react with PBr5 to give ketones brominated in the α-positions.

  摘要 小环环酮在 CCl4 中与过量的 PCl5 反应（回流，1-3 天）得到相应的 1,1,2-三氯环烷烃，但与 PBr5 反应得到在 α 位溴化的酮。
• Diet and Exercise Habits of Patients with Diabetes, Dyslipidemia, Cardiovascular Disease or Hypertension
  作者：Marian L. Neuhouser、Debra L. Miller、Alan R. Kristal、Matt J. Barnett、Lawrence J. Cheskin

  DOI：10.1080/07315724.2002.10719241

  日期：2002.10

  Objective: The objective of this study was to determine whether free-living individuals diagnosed with diabetes, dyslipidemia, cardiovascular disease or hypertension follow standard dietary recommendations for treatment of these diet-modifiable disorders.Methods: Data are from 1,782 adult men and women who completed an annual clinic visit as part of a large study of diet and health. Usual dietary intake over the previous month was assessed with a self-administered food frequency questionnaire. Trained staff obtained a detailed medical history and information on health and exercise habits, measured height and weight, and collected a fasting blood specimen to measure total serum cholesterol, triglycerides and carotenoids. Multivariate, linear regression was used to test associations of diet-modifiable chronic diseases with diet and exercise habits.Results: 42% of the study sample reported at least one diet-modifiable disease or risk factor for disease. These individuals had higher total serum cholesterol (p < 0.001) and triglycerides p < 0.001) compared to those without these conditions. Diabetics consumed a greater percent of energy from fat (p < 0.01), and men with hypertension consumed a greater percent energy from saturated fat (p < 0.05) compared to those without these conditions. There were few other differences in dietary intake between diseased and healthy individuals. and on average, all participants had diets that were not consistent with recommended guidelines for prevention or treatment of these diet-modifiable disorders. Forty-six percent of all participants were overweight or obese, and BMI was significantly higher among participants with at least one diet-modifiable disorder (p < 0.001). Healthy and diseased participants exercised about 17 minutes per day, and compared to non-diabetics, persons with diabetes exercised with 25% less intensity (p < 0.05).Conclusion: Participants in this sample with diet-modifiable disorders reported that they are motivated to eat less fat, but most are still overweight or obese, consume a diet high in fat and low in fruits and vegetables and engage in very little physical exercise. New strategies are needed to help patients adopt and maintain healthful dietary practices that will reduce their risk.
• Backer; Wiggerink, Recueil des Travaux Chimiques des Pays-Bas, 1941, vol. 60, p. 463
  作者：Backer、Wiggerink

  DOI：——

  日期：——
• New class of mixed cuprate(I) reagents, lithium hetero(alkyl) cuprate(I), which allow selective alkyl group transfer
  作者：Gary H. Posner、Charles E. Whitten、Jeffrey J. Sterling

  DOI：10.1021/ja00804a041

  日期：1973.11
• Oxidation of organic sulphides. Part IV. Autoxidation of cyclohex-2-enyl methyl sulphide
  作者：L. Bateman、F. W. Shipley

  DOI：10.1039/jr9550001996

  日期：——