3,4,6,7-tetrahydro-9-(1,2-dihydro-6-methoxy-2-oxoquinolin-3-yl)-3,3,6,6-tetramethyl-2H-xanthene-1,8(5H,9H)-dione | 1616269-81-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3,4,6,7-tetrahydro-9-(1,2-dihydro-6-methoxy-2-oxoquinolin-3-yl)-3,3,6,6-tetramethyl-2H-xanthene-1,8(5H,9H)-dione
• 英文别名: 9-(6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione；9-(6-methoxy-2-oxo-1H-quinolin-3-yl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-dione
• CAS: 1616269-81-8
• 化学式: C₂₇H₂₉NO₅
• 分子量: 447.531
• InChiKey: LCKXIDSEQMLVDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  33
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯-6-甲氧基喹啉-3-甲醛 、 5,5-二甲基-1,3-环己二酮 在 水 作用下， 反应 1.5h， 以84%的产率得到3,4,6,7-tetrahydro-9-(1,2-dihydro-6-methoxy-2-oxoquinolin-3-yl)-3,3,6,6-tetramethyl-2H-xanthene-1,8(5H,9H)-dione
  参考文献：
  名称：

  Water mediated catalyst-free efficient domino synthesis of 9-(quinolin-2(1H)-one)-xanthene-1,8(5H,9H)-diones using parallel synthesizer

  摘要：

  DOI：

  10.1016/j.tetlet.2014.05.015

文献信息

• Water mediated catalyst-free efficient domino synthesis of 9-(quinolin-2(1H)-one)-xanthene-1,8(5H,9H)-diones using parallel synthesizer
  作者：Varadhan Krishnakumar、Badal Kumar Mandal、Fazlur-Rahman Nawaz Khan、Euh Duck Jeong

  DOI：10.1016/j.tetlet.2014.05.015

  日期：2014.7
• Efficient Synthesis and Evaluation of Antitumor Activities of Novel Functionalized 1,8-Naphthyridine Derivatives
  作者：Lei Fu、Xian Feng、Jian-Jun Wang、Zhan Xun、Jun-Die Hu、Juan-Juan Zhang、Yan-Wei Zhao、Zhi-Bin Huang、Da-Qing Shi

  DOI：10.1021/co500120b

  日期：2015.1.12

  An efficient synthesis of novel functionalized 1,8-naphthyridine and chromeno[2,3-b]quinoline derivatives via cascade reaction of 2-chloroquinoline-3-carbaldehyde and enaminones or cyclic 1,3-dicarbonyl compounds was developed. All of the 1,8-naphthyridine derivatives synthesized were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have high activities.