2,3,5,6-tetra(pyridin-4-yl)pyrazine | 874672-21-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,3,5,6-tetra(pyridin-4-yl)pyrazine
• 英文别名: tetra-2-pyridinylpyrazine；tetra-4-pyridylpyrazine；tpyprz；2,3,5,6-tetrapyridin-4-ylpyrazine
• CAS: 874672-21-6
• 化学式: C₂₄H₁₆N₆
• 分子量: 388.431
• InChiKey: WAAAVDZKACLRPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,5-噻吩二羧酸 、 zinc(II) nitrate hexahydrate 、 2,3,5,6-tetra(pyridin-4-yl)pyrazine 、 水 以 N,N-二甲基乙酰胺 、 乙腈 为溶剂， 反应 72.0h， 以20.8%的产率得到{Zn(2,5-thiophenedicarboxylate)(2,3,5,6-tetra(pyridin-4-yl)pyrazine)_0.5*H₂O}_n
  参考文献：
  名称：

  Two Zn(II)-based coordination polymers: treatment effect on the cardiac arrest induced by anesthesia by regulating Sirt1 expression

  摘要：

  By applying a mixed-ligand approach, two new Zn(II)-containing coordination polymers (CPs) with the chemical formula of {Zn(TDC)(TPP)(0.5)center dot H2O}(n) (1) and {[Zn-2(2,6-NDC)(2)(TPP)]center dot MeCN center dot 3H(2)O}(n) (2) (TPP = 2,3,5,6-tetra(pyridin-4-yl)pyrazine, H2TDC = 2,5-thiophenedicarboxylic acid, 2,6-H2NDC = 2,6-naphthalic acid), have been synthesized by a semi-rigid tetrapyridine ligand and auxiliary dicarboxylic ligands. In biological functional study, compounds 1 and 2 was investigated for the treatment of cardiac arrest induced by anesthesia. The cardiac arrest-cardiopulmonary resuscitation model was established, followed by the compounds given for treatment. The enzyme linked immunosorbent assay (ELISA) detection kit was used in this experiment for measuring the content of cardiac troponin T and B brain natriuretic peptide after compounds treatment. Next, the relative expression level of the Sirt1 in the rat myocardial tissue was measured with real time reverse transcription-polymerase chain reaction (RT-PCR).

  DOI：

  10.1080/24701556.2020.1841230

文献信息

• Solid-State Coordination Chemistry of the Oxomolybdate−Organodiphosphonate/Nickel−Organoimine System:  Structural Influences of the Secondary Metal Coordination Cation and Diphosphonate Tether Lengths
  作者：Eric Burkholder、Vladimir Golub、Charles J. O'Connor、Jon Zubieta

  DOI：10.1021/ic049201k

  日期：2004.11.1

  one-dimensional materials [[Ni(2)(tpyprz)(2)]Mo(5)O(15)[O(3)P(CH(2))(4)PO(3)]]x6.65H(2)O (6x6.65H(2)O) and [[Ni(2)(tpyprz)(2)]Mo(5)O(15)[O(3)P(CH(2))(5)PO(3)]]x3.75H(2)O (8x3.75H(2)O), the two-dimensional phases [[Ni(4)(tpyprz)(3)][Mo(5)O(15)(O(3)PCH(2)CH(2)PO(3))](2)]x23H(2)O (3x23H(2)O) and [[Ni(3)(tpyprz)(2)(H(2)O)(2)](Mo(5)O(15))(Mo(2)O(4)F(2))[O(3)P(CH(2))(3)PO(3)](2) ]x8H(2)O (5x8H(2)O), and the three-dimensional

  钼酸盐源，镍（II）盐，四-2-吡啶基吡嗪（tpyprz）和有机二膦酸H（2）O（3）P（CH（2））（n）（）PO（3）的水热反应不同系链长度的）H（2）（n = 1-5）产生了一系列钼磷膦酸镍家族的有机-无机杂化材料。结构化学的一个持久性特征是[Mo（5）O（15）（O（3）PR）（2）]（4）（-）簇作为分子构件的存在，正如一个维材料[[Ni（2）（tpyprz）（2）] Mo（5）O（15）[O（3）P（CH（2））（4）PO（3）]] x6.65H（2 ）O（6x6.65H（2）O）和[[Ni（2）（tpyprz）（2）] Mo（5）O（15）[O（3）P（CH（2））（5）PO（ 3）]] x3.75H（2）O（8x3.75H（2）O），二维相[[Ni（4）（tpyprz）（3）] [Mo（5）O（15）（O （3）PCH（2）CH（2）PO（3））]（2）] x23H（2）O
• An oxide chain constructed from octamolybdate, a Keggin anion and a copper (II) – Tetrapyridylpyrazine binuclear unit
  作者：N. Gabriel Armatas、Wayne Ouellette、Joshua Pelcher、Jon Zubieta

  DOI：10.1016/j.inoche.2009.06.005

  日期：2009.8

  The hydrothermal reaction of MoO3, CuSO4 center dot 5H(2)O, tetra-4-pyridylpyrazine (tpyprz). and diphenyidiarsonic acid in water at 140 degrees C for 48 h yielded the one-dimensional material [Cu-2(tpyprz)(H2O)(3)}(2)Mo8O26} (Mo12O36(AsO4)}]center dot 8H(2)O (1 center dot H2O). The chain structure of 1 center dot 8H(2)O is constructed from alternating beta-octamolybdate clusters and molybdoarsonate Keggin clusters linked through Cu-2(tpyprz)(H2O)(3)}(4+) binuclear subunits. The Cu(II) sites are inequivalent with one copper bonding to two pyridyl donors and a pyrazine nitrogen of one terminus of the tpyprz ligand, two aqua ligands and an oxo-group of the beta - Mo8O264- cluster while the second copper site coordinates to the nitrogen donors of the other terminus of the tpyprz ligand, an aqua group, a terminal oxo-group of the beta - Mo8O264- cluster and a terminal oxo-group of the mixed valence (Mo11MoO36)-Mo-VI-O-V(AsO4)}(4-) Cluster. Crystal data: C48H60AsCu4Mo20N12O80: FW = 4332.96 Tri-clinic P (1) over bar, a = 12.5087(5) angstrom, b = 13.6681(6) angstrom, c = 14.8980(6) angstrom. alpha = 92.196(1)degrees, beta = 97.046(1)degrees, gamma = 97.751(1)degrees, Z = 1, D-calc = 2.877 g cm(-3); structure solution and refinement based on 12,333 reflections (Mo K-alpha, lambda = 0.71073 angstrom) converged at R-1 = 0.0540 and wR(2) = 0.1115. (C) 2009 Elsevier B.V. All rights reserved.