(6-chloro-2-(3-nitrophenyl)quinoline) | 912283-95-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (6-chloro-2-(3-nitrophenyl)quinoline)
• 英文别名: 6-Chloro-2-(3-nitrophenyl)quinoline
• CAS: 912283-95-5
• 化学式: C₁₅H₉ClN₂O₂
• 分子量: 284.702
• InChiKey: UZKBWRBVKSQYQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 1,2,3,4,5,6,7,8-八硫杂环辛烷 作用下， 反应 0.17h， 生成 (6-chloro-2-(3-nitrophenyl)quinoline)
  参考文献：
  名称：

  In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels–Alder reactions

  摘要：

  Diverse polyfunctionalized quinolines, easily prepared using Lewis acid-catalyzed imino Diels-Alder reactions between corresponding aldimines, were tested for antifungal properties against standardized as well as clinical isolates of clinically important fungi. Among them, 4-pyridyl derivatives displayed the best activities mainly against dermatophytes. The activity appears not to be related neither to the lipophilicity nor to the basicity of compounds. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.07.079

文献信息

• Three-Component Povarov Reaction with Alcohols as Alkene Precursors: Efficient Access to 2-Arylquinolines
  作者：Xinjian Li、Qi Xing、Pan Li、Jingjing Zhao、Fuwei Li

  DOI：10.1002/ejoc.201601343

  日期：2017.1.18

  An atom-economic and efficient approach to the synthesis of 2-arylquinolines has been developed. The protocol involves an iron-catalysed cascade N-alkylation/aerobic oxidation/Povarov reaction, and the desired quinolines were prepared in moderate to excellent yields from readily accessible anilines, aldehydes, and EtOH/nPrOH, with water as the only side-product. The aniline substrates also act as a

  已开发出一种原子经济且有效的合成 2-芳基喹啉的方法。该协议涉及铁催化的级联 N-烷基化/有氧氧化/Povarov 反应，所需的喹啉是从易于获得的苯胺、醛和 EtOH/nPrOH 中以中等至极好的收率制备的，水作为唯一的副产品。苯胺底物还通过原位 N-烷基化/氧化过程充当 EtOH/nPrOH 的可回收转移介质。这使得 EtOH/nPrOH 成为一种经济且环保的烯烃前体和溶剂。