tetrahydro-[2,2']bifuranyl-5,5'-dione | 35416-66-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: tetrahydro-[2,2']bifuranyl-5,5'-dione
• 英文别名: tetrahydro-[2,2']bifuryl-5,5'-dione；Tetrahydro-[2,2']bifuryl-5,5'-dion；5-(5-Oxooxolan-2-yl)oxolan-2-one
• CAS: 35416-66-1
• 化学式: C₈H₁₀O₄
• 分子量: 170.165
• InChiKey: FVFKPNJLMIYAQM-UHFFFAOYSA-N

物化性质

• 熔点：
  104 °C(Solv: chloroform (67-66-3); ligroine (8032-32-4))
• 沸点：
  424.8±28.0 °C(Predicted)
• 密度：
  1.348±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tetrahydro-[2,2']bifuranyl-5,5'-dione 在 1,4-二氧六环 、 copper(II) oxide 、 barium(II) oxide 作用下， 225.0 ℃ 、19.61 MPa 条件下， 生成 octane-1,4,5,8-tetraol
  参考文献：
  名称：

  Bifurandione. III. Addition and Ring-opening Reactions

  摘要：

  DOI：

  10.1021/ja01523a048
• 作为产物：
  描述：

  (E)-[2,2']bifurylidene-5,5'-dione 在 palladium on activated charcoal 作用下， 生成 4-(5-oxo-tetrahydro-[2]furyl)-butyric acid 、 tetrahydro-[2,2']bifuranyl-5,5'-dione
  参考文献：
  名称：

  Albanesi; Tovaglieri, Chimica e l'Industria (Milan, Italy), 1959, vol. 41, p. 189,194

  摘要：

  DOI：

文献信息

• [EN] METHOD OF MANUFACTURE OF OCTANEDIOIC ACID, PRECURSORS, AND DERIVATIVES<br/>[FR] PROCÉDÉ DE FABRICATION D'ACIDE OCTANE-DIOÏQUE, PRÉCURSEURS ET DÉRIVÉS
  申请人：SEGETIS INC

  公开号：WO2014150384A1

  公开（公告）日：2014-09-25

  A method for the manufacture of 1,8-octanedioic acid comprises: reacting gamma-valerolactone with an alcohol in the presence of an acid or a base catalyst to provide an alkyl pentenoate, converting the alkyl pentenoate in the presence of a metathesis initiator to provide the dialkyl octenedioate, reacting the dialkyl octenedioate with hydrogen in the presence of a hydrogenation catalyst to provide a dialkyl 1,8-octanedioate and hydrolyzing the dialkyl 1,8-octanedioate to provide the 1,8-octanedioic acid.

  一种制备1,8-辛二酸的方法，包括：在酸性或碱性催化剂的存在下，将γ-戊内酯与醇反应，得到烷基戊烯酸酯；在交换催化剂存在下，将烷基戊烯酸酯转化为二烷基辛二烯酸酯；在加氢催化剂的存在下，将二烷基辛二烯酸酯与氢气反应，得到二烷基1,8-辛二酸；并将二烷基1,8-辛二酸水解，得到1,8-辛二酸。
• Polyester nanogel core star polymers for delivery of therapeutic agents
  申请人：International Business Machines Corporation

  公开号：US10392470B2

  公开（公告）日：2019-08-27

  Amphiphilic star polymers were prepared having superior loading properties for delivery of hydrophobic biologically active materials intended for use in medical, cosmetic, and other applications. The star polymers comprise a plurality block copolymer arms linked to a crosslinked polyester core. The monovalent arms comprise a peripheral poly(ethylene oxide) block (PEG block) and a polyester block, which is linked to the core. The sidechain substituents of the polyester block substantially improve the loading capacity of the star polymer for CoQ10 and other hydrophobic materials.

  制备出的两亲星型聚合物具有优异的负载性能，可用于输送疏水性生物活性材料，供医疗、化妆品和其他应用使用。星型聚合物由多个嵌段共聚物臂组成，嵌段共聚物臂与交联聚酯芯相连。单价臂包括外围的聚环氧乙烷嵌段（PEG 嵌段）和与核心相连的聚酯嵌段。聚酯嵌段的侧链取代基大大提高了星形聚合物对 CoQ10 和其他疏水性材料的负载能力。
• Co-delivery of cholesterol lowering drugs and nutraceuticals
  申请人：International Business Machines Corporation

  公开号：US10457759B2

  公开（公告）日：2019-10-29

  Star polymer occlusion complexes were prepared comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent amphiphilic polymer arms, ii) a nutraceutical (such as coenzyme Q10), and iii) a cholesterol-lowering drug (such as simvastatin). An initial occlusion complex formed with the nutraceutical and the star polymer exhibited improved binding properties for the cholesterol-lowering drug, resulting in improved loading efficiencies for the cholesterol-lowering drug. The star polymer occlusion complexes have utility in the medical treatment of high blood cholesterol.

  制备的星形聚合物闭塞复合物包括 i) 两性单分子星形聚合物，其交联核心与 6 个或更多独立的两性聚合物臂共价连接；ii) 营养保健品（如辅酶 Q10）；iii) 降胆固醇药物（如辛伐他汀）。营养保健品与星形聚合物形成的初始闭塞复合物对降低胆固醇药物的结合性能有所改善，从而提高了降低胆固醇药物的装载效率。星形聚合物闭塞复合物可用于治疗高血脂。
• SHAH MAYUR; TASCHNER M. J.; KOSER G. F.; RACH N. L.; JENKINS TH. E.; CYR +, TETRAHEDRON LETT., 27,(1986) N 45, 5437-5440
  作者：SHAH MAYUR、 TASCHNER M. J.、 KOSER G. F.、 RACH N. L.、 JENKINS TH. E.、 CYR +

  DOI：——

  日期：——
• STAR POLYMER NANOSHELLS AND METHODS OF PREPARATION THEREOF
  申请人：Lee Victor Yee-Way

  公开号：US20120237447A1

  公开（公告）日：2012-09-20

  A nanoshell is disclosed, comprising a star polymer occlusion complex comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent polymer arms, and ii) a cargo material occluded in the star polymer; and a shell comprising an inorganic material in contact with a peripheral surface of the star polymer occlusion complex.