3',4'-Dihydroxy-beta-naphthoflavone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3',4'-Dihydroxy-beta-naphthoflavone
• 英文别名: 3',4'-dihydroxy-β-naphthoflavone；3',4',5'-trihydroxy flavone；3-(3,4-dihydroxy-phenyl)-benzo[f]chromen-1-one；3-(3,4-Dihydroxy-phenyl)-benzo[f]chromen-1-on；3-(3,4-Dihydroxyphenyl)benzo[f]chromen-1-one
• 化学式: C₁₉H₁₂O₄
• 分子量: 304.302
• InChiKey: CHJYKPALQWHBFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-乙酰基-2-萘酚 在 乙醇 、 氢碘酸 、 sodium ethanolate 、 phosphorus pentoxide 、 乙酸酐 、 溶剂黄146 、 苯 作用下， 生成 3',4'-Dihydroxy-beta-naphthoflavone
  参考文献：
  名称：

  CCCLXI：色酮组中的合成实验。第四部分1：4-βα-萘并吡喃酮

  摘要：

  DOI：

  10.1039/jr9310002591

文献信息

• NEUROPROTECTIVE POLYPHENOL ANALOGS
  申请人：Salk Institute for Biological Studies

  公开号：US20140186328A1

  公开（公告）日：2014-07-03

  The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and/or antioxidant properties. The neuroprotective polyphenol compounds are useful for promoting, enhancing and/or increasing neuron protection, growth and/or regeneration. The polyphenol compounds further find use for increasing and or maintaining intracellular glutathione (GSH) levels. The polyphenol compounds are also useful for treating, preventing, mitigating and/or delaying neurodegenerative conditions, including diabetes, Parkinson's disease, Huntington's disease, Alzheimer's disease, non-Alzheimer's dementias, multiple sclerosis, traumatic brain injury, spinal cord injury or ALS.
• POLYPHENOL ANALOGS TO TREAT ISCHEMIA
  申请人：Lapchak Paul A.

  公开号：US20140186329A1

  公开（公告）日：2014-07-03

  The present invention provides methods of use of polyphenol compounds for treating, preventing, mitigating and delaying ischemia or a condition where ischemia occurs. In one embodiment, the method comprises providing a polyphenol analog; and administering the polyphenol analog to a subject to treat ischemia or a condition where ischemia occurs. Various embodiments of the present invention are useful for the treatment of patients having, or at risk for, any of (1) ischemic stroke, (2) hemorrhagic stroke, (3) cardiovascular disease, (4) ischemia related spinal cord injury, (5) ischemia in diabetic patients, or (6) embolic stroke. For example, use of the polyphenol compounds can maintain glutathione levels in the patient.
• US9744164B2
  申请人：——

  公开号：US9744164B2

  公开（公告）日：2017-08-29
• CCCLXI.—Synthetical experiments in the chromone group. Part IV. 1 : 4-βα-Naphthapyrones
  作者：Bala Krishna Menon、Krishnasami Venkataraman

  DOI：10.1039/jr9310002591

  日期：——