3-[4-[(4-Chloro-5-formyl-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophene-2-sulfonamide | 304462-30-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[4-[(4-Chloro-5-formyl-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophene-2-sulfonamide
• CAS: 304462-30-4
• 化学式: C₂₅H₂₄ClN₃O₃S₂
• 分子量: 514.069
• InChiKey: DDKVVAQCROHKSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  132
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-[4-[(4-Chloro-5-formyl-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophene-2-sulfonamide 在 氢氧化钾 、 potassium carbonate 作用下， 以 乙二醇二甲醚 为溶剂， 80.0 ℃ 、220.0 kPa 条件下， 反应 8.0h， 生成 AVE 0991
  参考文献：
  名称：

  ¹⁴C-Labeled and Large-Scale Synthesis of the Angiotensin-(1−7)-receptor Agonist AVE 0991 by Cross-Coupling Reactions

  摘要：

  The synthesis of C-14-labeled AVE 0991 (C-14-1a) and large-scale synthesis of AVE 0991 (1a) are described. In the key step of the synthesis, the C-C coupling reaction of the imidazole (2) and thiophene (3) building blocks was studied under Suzuki and Stille reaction conditions, respectively. Suzuki reaction gave only moderate yields, whereas the best results were obtained under Stille reaction conditions with up to 64% yield.

  DOI：

  10.1021/jo034372c
• 作为产物：
  描述：

  对溴溴苄 在 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 120.0h， 生成 3-[4-[(4-Chloro-5-formyl-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophene-2-sulfonamide
  参考文献：
  名称：

  ¹⁴C-Labeled and Large-Scale Synthesis of the Angiotensin-(1−7)-receptor Agonist AVE 0991 by Cross-Coupling Reactions

  摘要：

  The synthesis of C-14-labeled AVE 0991 (C-14-1a) and large-scale synthesis of AVE 0991 (1a) are described. In the key step of the synthesis, the C-C coupling reaction of the imidazole (2) and thiophene (3) building blocks was studied under Suzuki and Stille reaction conditions, respectively. Suzuki reaction gave only moderate yields, whereas the best results were obtained under Stille reaction conditions with up to 64% yield.

  DOI：

  10.1021/jo034372c

文献信息

• ¹⁴C-Labeled and Large-Scale Synthesis of the Angiotensin-(1−7)-receptor Agonist AVE 0991 by Cross-Coupling Reactions
  作者：Volker Derdau、Raymond Oekonomopulos、Gerrit Schubert

  DOI：10.1021/jo034372c

  日期：2003.6.1

  The synthesis of C-14-labeled AVE 0991 (C-14-1a) and large-scale synthesis of AVE 0991 (1a) are described. In the key step of the synthesis, the C-C coupling reaction of the imidazole (2) and thiophene (3) building blocks was studied under Suzuki and Stille reaction conditions, respectively. Suzuki reaction gave only moderate yields, whereas the best results were obtained under Stille reaction conditions with up to 64% yield.