N-Acetyl-L-leucyl-L-leucyl-L-argininal | 24365-47-7

• 物质功能分类: 生物化工 - 抑制剂
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Acetyl-L-leucyl-L-leucyl-L-argininal
• 英文别名: 2-acetamido-N-[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide
• CAS: 24365-47-7
• 化学式: C₂₀H₃₈N₆O₄
• 分子量: 426.6
• InChiKey: GDBQQVLCIARPGH-UHFFFAOYSA-N

物化性质

• 沸点：
  541.98°C (rough estimate)
• 密度：
  1.1865 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  30
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  169
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• Compositions, and kits comprising targeted aldehyde or acetal protease inhibitor compounds for treating muscle disorders
  申请人：Stracher Alfred

  公开号：US20080039531A1

  公开（公告）日：2008-02-14

  Described herein are compounds that comprise a carrier residue that is or is an analog of carnitine, an optional linker group, and a residue of a protease inhibitor comprising an aldehyde group or acetal derivatives of the aldehyde group, and pharmaceutical compositions and kits thereof. The compounds, compositions, and kits are useful for treating muscle disorders in animals and humans that result from the undesired activity of biological proteases. The compounds of the invention are particularly effective as calpain inhibitors, and can be used to treat the resulting muscular disorders, exemplified by Duchenne or Becker muscular dystrophy.

  本文介绍的是一种化合物，该化合物包括一个载体残基，该载体残基是肉碱或其类似物，一个可选的连接基团，以及一个蛋白酶抑制剂残基，该蛋白酶抑制剂残基包括一个醛基或醛基的缩醛衍生物，以及其制备的药物组合物和试剂盒。这些化合物、组合物和试剂盒可用于治疗动物和人类的肌肉疾病，这些肌肉疾病是由生物蛋白酶的不良活性引起的。本发明的化合物特别有效地作为卡尔帕因抑制剂，并可用于治疗由此引起的肌肉疾病，例如杜氏或贝克肌肉萎缩症。
• Promoting animal and plant growth with protease inhibitors
  申请人：GENETIC DIAGNOSTIC CORPORATION

  公开号：EP0144993A2

  公开（公告）日：1985-06-19

  A method of promoting the more rapid growth of an animal or plant, which comprises administering to said animal, to a food source for said animal, to a plant or to a plant habitat a growth-promoting effective amount of a protease inhibitor such as leupeptin. The protease inhibitor can be incorporated into an animal feed or supplement containing a food base. It apparently functions by inhibiting proteases which degrade proteins, and thus reduce the growth of the host.

  一种促进动物或植物更快生长的方法，包括向所述动物、所述动物的食物来源、植物或植物栖息地施用促进生长有效量的蛋白酶抑制剂（如利普汀）。蛋白酶抑制剂可加入含有食物基础的动物饲料或补充剂中。它的作用显然是抑制蛋白质降解的蛋白酶，从而减少宿主的生长。
• Targeting CAPN9/CAPNS2 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies
  申请人：The Johns Hopkins University

  公开号：US11219670B2

  公开（公告）日：2022-01-11

  Provided herein are, inter alia, compositions and methods for identifying and using agents capable of inhibiting myofibroblast transition as well as methods for treating diseases associated with the same in a subject in need thereof.

  本文特别提供了用于鉴定和使用能够抑制肌成纤维细胞转化的制剂的组合物和方法，以及用于治疗与之相关的疾病的方法。
• Compounds for Treating Neurologic Diseases, Otologic Diseases, or Ophthalmologic Diseases and Methods of Use Thereof
  申请人：Stracher Alfred

  公开号：US20080200399A1

  公开（公告）日：2008-08-21

  Described herein are compounds and methods for treating or preventing a neurologie, otologic, or ophthalmologic disease in a subject. Also described herein are compounds that can be used as therapeutics.
• Targeted Delivery of Pharmaceutical Compounds
  申请人：Stracher Alfred

  公开号：US20090227522A1

  公开（公告）日：2009-09-10

  Techniques are provided for targeting a pharmaceutically active compound using, as a carrier, a molecule (or molecules) having greater affinity for a particular site in a living organism's body than for other sites therein. A compound of the formula B-L-A is provided, where B represents the residue of a small synthetic molecule, preferably one that is approved for human use, having a greater affinity for a particular site in a patient's body than for other sites in the patient's body, L represents a direct bond or a linking group, and A represents the residue of a pharmaceutically active compound.