3-(2-Carboxy-5-methoxy-phenyl)-propionsaeure | 83960-80-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-Carboxy-5-methoxy-phenyl)-propionsaeure
• 英文别名: 3-(2-carboxy-5-methoxy-phenyl)-propionic acid；2-(2-Carboxyethyl)-4-methoxybenzoic acid
• CAS: 83960-80-9
• 化学式: C₁₁H₁₂O₅
• 分子量: 224.213
• InChiKey: BPYBGOTVHXEXBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(2-Carboxy-5-methoxy-phenyl)-propionsaeure 在 palladium on activated charcoal 盐酸 、 lithium aluminium tetrahydride 、 氨 、 氢气 、 sodium 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Reichel, Curtis J.; Bryson, Thomas A., Heterocycles, 1982, vol. 18, p. 277 - 280

  摘要：

  DOI：
• 作为产物：
  描述：

  6-甲氧基-1,2,3,4-四氢萘-1-基乙酸酯 在 potassium permanganate 、 potassium hydrogensulfate 、 丙酮 作用下， 120.0 ℃ 、2.93 kPa 条件下， 生成 3-(2-Carboxy-5-methoxy-phenyl)-propionsaeure
  参考文献：
  名称：

  A Glucomannan and Chitosan Fiber Supplement Decreases Plasma Cholesterol and Increases Cholesterol Excretion in Overweight Normocholesterolemic Humans

  摘要：

  Objective: Both chitosan and glucomannan have demonstrated hypocholesterolemic effects. A recent study in rats indicates that the combination of the two is also a potent hypocholesterolemic agent that increases fecal fat excretion. The objective of the present study was to determine the hypocholesterolemic effect of a supplement containing equal amounts of chitosan and glucomannan on blood lipid concentrations and fecal excretion of fat, neutral sterols and bile acids.Methods: Twenty-one overweight normocholesterolemic subjects (I I males and 10 females) were fed 2.4 g/day of a supplement containing equal amounts of chitosan and glucomannan. Prior to taking the supplement (initial period) and after 28 days (final period), blood was drawn for measurement of serum lipids and a three-day fecal sample collected for determination of fat, neutral sterol and bile acid excretion. Subjects maintained their normal dietary and activity patterns during the study.Results: Caloric intake and intake of fat and dietary fiber (excluding the supplement) did not differ between the initial and final periods. Serum total, HDL and LDL cholesterol concentrations were significantly lower (P < 0.05) in the final period compared to the initial period. Serum triacylglycerol concentration did not change between periods. There was a trend towards greater fecal excretion of neutral sterols and bile acids (p = 0.13 and 0.16, respectively) in the final period. However. fecal fat excretion did not differ between periods.Conclusions: Serum cholesterol reduction by a chitosan/glucomannan supplement is likely mediated by increased fecal steroid excretion and is not linked to fat excretion.

  DOI：

  10.1080/07315724.2002.10719246

文献信息

• A Plan for Distinguishing between Some Five- and Six-membered Ring Ketones
  作者：William S. Johnson、Wesley E. Shelberg

  DOI：10.1021/ja01226a038

  日期：1945.10
• Schick, H.; Welzel, H.-P.; Schwarz, S., Journal fur praktische Chemie (Leipzig 1954), 1982, vol. 324, # 4, p. 550 - 556
  作者：Schick, H.、Welzel, H.-P.、Schwarz, S.、Truckenbrodt, G.

  DOI：——

  日期：——
• Girija, Talupuru; Shanker, P. Sathya; Rao, G. S. R. Subba, Journal of the Chemical Society. Perkin transactions I, 1991, # 6, p. 1467 - 1471
  作者：Girija, Talupuru、Shanker, P. Sathya、Rao, G. S. R. Subba

  DOI：——

  日期：——
• The Dimerization of 6-Methoxy-3,4-dihydronaphthalene
  作者：R. B. Woodward、R. H. Eastman

  DOI：10.1021/ja01233a003

  日期：1944.5
• A Glucomannan and Chitosan Fiber Supplement Decreases Plasma Cholesterol and Increases Cholesterol Excretion in Overweight Normocholesterolemic Humans
  作者：Daniel D. Gallaher、Cynthia M. Gallaher、Gregory J. Mahrt、Timothy P. Carr、Carolyn H. Hollingshead、Robert Hesslink、John Wise

  DOI：10.1080/07315724.2002.10719246

  日期：2002.10

  Objective: Both chitosan and glucomannan have demonstrated hypocholesterolemic effects. A recent study in rats indicates that the combination of the two is also a potent hypocholesterolemic agent that increases fecal fat excretion. The objective of the present study was to determine the hypocholesterolemic effect of a supplement containing equal amounts of chitosan and glucomannan on blood lipid concentrations and fecal excretion of fat, neutral sterols and bile acids.Methods: Twenty-one overweight normocholesterolemic subjects (I I males and 10 females) were fed 2.4 g/day of a supplement containing equal amounts of chitosan and glucomannan. Prior to taking the supplement (initial period) and after 28 days (final period), blood was drawn for measurement of serum lipids and a three-day fecal sample collected for determination of fat, neutral sterol and bile acid excretion. Subjects maintained their normal dietary and activity patterns during the study.Results: Caloric intake and intake of fat and dietary fiber (excluding the supplement) did not differ between the initial and final periods. Serum total, HDL and LDL cholesterol concentrations were significantly lower (P < 0.05) in the final period compared to the initial period. Serum triacylglycerol concentration did not change between periods. There was a trend towards greater fecal excretion of neutral sterols and bile acids (p = 0.13 and 0.16, respectively) in the final period. However. fecal fat excretion did not differ between periods.Conclusions: Serum cholesterol reduction by a chitosan/glucomannan supplement is likely mediated by increased fecal steroid excretion and is not linked to fat excretion.