2-nonyl-3-hydroxy-4(1H)-quinolone | 521313-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-nonyl-3-hydroxy-4(1H)-quinolone
• 英文别名: 2-nonyl-3-hydroxy-4-quinolone；C9-PQS；NHQ；3,4-Quinolinediol, 2-nonyl-；3-hydroxy-2-nonyl-1H-quinolin-4-one
• CAS: 521313-36-0；1259944-03-0
• 化学式: C₁₈H₂₅NO₂
• 分子量: 287.402
• InChiKey: IQZSNBAQPVKMLG-UHFFFAOYSA-N

物化性质

• 沸点：
  442.1±40.0 °C(Predicted)
• 密度：
  1.096±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-氯十一烷-2-酮 、 邻氨基苯甲酸 在 N,N-二异丙基乙胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 0.67h， 生成 2-nonyl-3-hydroxy-4(1H)-quinolone
  参考文献：
  名称：

  Microwave and flow syntheses of Pseudomonasquinolone signal (PQS) and analogues

  摘要：

  报告采用微波和流动方法对假单胞菌喹啉信号（PQS）及其相关结构类似物进行的便捷合成。

  DOI：

  10.1039/c0ob00652a

文献信息

• Alkyl quinolones as biomarkers of pseudomonas aeruginosa infection and uses thereof
  申请人：The University of Nottingham

  公开号：US10139406B2

  公开（公告）日：2018-11-27

  A method of determining the P. aeruginosa or related species infection status of a subject comprising: (i) providing a sample of material obtained from the subject; (ii) determining the level of one or more alkyl quinolones or metabolites thereof produced by P. aeruginosa or a related species in the sample

  一种确定受试者铜绿假单胞菌或相关菌种感染状况的方法，包括：(i) 提供从受试者身上获取的材料样本；(ii) 确定样本中铜绿假单胞菌或相关菌种产生的一种或多种烷基喹诺酮类药物或其代谢物的水平
• ALKYL QUINOLONES AS BIOMARKERS OF PSEUDOMONAS AERUGINOSA INFECTION AND USES THEREOF
  申请人：The University Of Nottingham

  公开号：EP2997382A1

  公开（公告）日：2016-03-23
• Methods for Identifying Candidate Compounds for Treating, Reducing, or Preventing Pathogenic Infections
  申请人：Rahme Laurence

  公开号：US20070292851A1

  公开（公告）日：2007-12-20

  Disclosed are methods for identifying candidate compounds for treating, reducing, or preventing a pathogenic infection, the methods including: (a) contacting a pathogenic cell with a candidate compound; and (b) measuring the production of a molecule selected from the group consisting of an 4-hydroxy-2-alkylquinoline (HAQ) molecule, 4-hydroxy-2-heptylquinoline (HHQ) molecule, or a derivative or precursor thereof in the cell, a candidate compound that reduces the production relative to production of the molecule by a cell not contacted with the candidate compound, identifying a candidate compound useful for treating, reducing, or preventing a pathogenic infection.
• US8906602B2
  申请人：——

  公开号：US8906602B2

  公开（公告）日：2014-12-09
• [EN] METHODS FOR IDENTIFYING CANDIDATE COMPOUNDS FOR TREATING, REDUCING, OR PREVENTING PATHOGENIC INFECTIONS<br/>[FR] PROCEDES D'IDENTIFICATION DE COMPOSES CANDIDATS POUR TRAITER, REDUIRE OU PREVENIR DES INFECTIONS PATHOGENES
  申请人：GEN HOSPITAL CORP

  公开号：WO2005069989A2

  公开（公告）日：2005-08-04

  Disclosed are methods for identifying candidate compounds for treating, reducing, or preventing a pathogenic infection, the methods including: (a) contacting a pathogenic cell with a candidate compound; and (b) measuring the production of a molecule selected from the group consisting of an 4-hydroxy-2-alkylquinoline (HAQ) molecule, 4-hydroxy-2-heptylquinoline (HHQ) molecule, or a derivative or precursor thereof in the cell, a candidate compound that reduces the production relative to production of the molecule by a cell not contacted with the candidate compound, identifying a candidate compound useful for treating, reducing, or preventing a pathogenic infection.