2-<1,2-Dioxo-butyl>-furan | 1438-90-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-<1,2-Dioxo-butyl>-furan
• 英文别名: Ethyl 2-furanyl diketone；1-(furan-2-yl)butane-1,2-dione
• CAS: 1438-90-0
• 化学式: C₈H₈O₃
• 分子量: 152.15
• InChiKey: IWMXBRWYPMCNQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  47.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-<1,2-Dioxo-butyl>-furan 在 甲酸 、 [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I) 、 N,N'-bis(trimethylsilyl)sulfamide 、 三氟化硼乙醚 、 三乙胺 作用下， 以 甲苯 、 乙腈 为溶剂， 反应 8.0h， 生成 4-ethyl-3-(furan-2-yl)-4,5-dihydro-1,2,5-thiadiazoline-1,1-dioxide
  参考文献：
  名称：

  Enantioselective Synthesis of 3,4-Disubstituted cis- and trans-1,2,5-Thiadiazolidine-1,1-dioxides as Precursors for Chiral 1,2-Diamines

  摘要：

  Both, cis- and trans-3,4-disubstituted thiadiazolidines 5 and 6 can enantioselectively be obtained from thiadiazoles 2 which, in turn, are efficiently prepared from the respective 1,2-diketone by an improved protocol. An asymmetric ruthenium-catalyzed transfer hydrogenation followed by a diastereoselective hydride addition furnishes exclusively the cis-isomers 5 which, under acidic conditions, undergo a novel isomerization into the trans-isomers 6. These cyclic sulfamides can be transformed into 1,2-diamines as well as 2,3-diamino acids.

  DOI：

  10.1021/ol3034753
• 作为产物：
  描述：

  糠醛 、 丙醛 在 3,4-二甲基-5-(2-羟乙基)碘代噻唑 、 三乙胺 、 bismuth(III) oxide 、 溶剂黄146 作用下， 以35%的产率得到2-<1,2-Dioxo-butyl>-furan
  参考文献：
  名称：

  Enantioselective Synthesis of 3,4-Disubstituted cis- and trans-1,2,5-Thiadiazolidine-1,1-dioxides as Precursors for Chiral 1,2-Diamines

  摘要：

  Both, cis- and trans-3,4-disubstituted thiadiazolidines 5 and 6 can enantioselectively be obtained from thiadiazoles 2 which, in turn, are efficiently prepared from the respective 1,2-diketone by an improved protocol. An asymmetric ruthenium-catalyzed transfer hydrogenation followed by a diastereoselective hydride addition furnishes exclusively the cis-isomers 5 which, under acidic conditions, undergo a novel isomerization into the trans-isomers 6. These cyclic sulfamides can be transformed into 1,2-diamines as well as 2,3-diamino acids.

  DOI：

  10.1021/ol3034753

文献信息

• Luminescent oxygen sensor based on a lanthanide complex
  申请人：C.R. BARD, INC.

  公开号：EP0259951A2

  公开（公告）日：1988-03-16

  An oxygen sensor is provided for determination of the partial pressure of oxygen. In one aspect, the invention consists of oxygen-­quenchable luminescent lanthanide complexes for an oxygen sensor. The complexes are oxygen-quenchable even though immobilized in a solid matrix, such as a solid polymeric matrix, and preferably are terbium complexes of Schiff base of β-diketone ligands. Certain preferred processes are described for improving the oxygen sensitivity of the lanthanide complexes. In another aspect, the invention consists of a combination measuring and reference analyte sensor containing both quenchable and nonquenchable luminescent material. The materials luminesce at different wavelengths and thus may be transmitted together down a single optical fiber and later descrimininated by means of filters and separately detected. In a third aspect, the invention consists of a low-noise phosphorescent analyte sensor employing a gatable detector. By use of an analyte-quenchable material having a relatively long-lived phosphorescence, a pulsed excitation source, and selectively coupling the detector after the excitation source is off and any short-lived background luminescence has ended, a low-noise output signal consisting of the long-lived phosphorescence is selectively detected and the concentration of the analyte determined therefrom. In a preferred embodiment, all aspects of the invention are combined to produce a miniature in vivo oxygen sensor for use in the narrow blood vessels of the body.

  本发明提供了一种用于测定氧分压的氧传感器。一方面，本发明包括用于氧传感器的可氧淬灭发光镧系配合物。这些配合物即使固定在固体基质（如固体聚合物基质）中也可被氧淬灭，最好是β-二酮配体的希夫碱铽配合物。本发明描述了某些优选工艺，用于改善镧系配合物的氧敏感性。另一方面，本发明包括一种测量和参考分析物组合传感器，其中包含可淬灭和不可淬灭发光材料。这些材料以不同的波长发光，因此可以一起通过一根光纤进行传输，然后通过滤波器进行分辨并分别进行检测。第三方面，本发明包括一种低噪声磷光分析传感器，该传感器采用了可门控检测器。通过使用具有相对长寿命磷光的可分析淬灭材料、脉冲激发源，并在激发源关闭和任何短寿命背景发光结束后选择性地耦合检测器，可选择性地检测到由长寿命磷光组成的低噪声输出信号，并由此确定分析物的浓度。在一个优选的实施方案中，本发明的所有方面结合在一起，产生了一个微型体内氧传感器，可用于人体狭窄的血管中。
• Excitation and detection apparatus for remote sensor connected by optical fiber
  申请人：C.R. BARD, INC.

  公开号：EP0283289A2

  公开（公告）日：1988-09-21

  Sensing apparatus for remote sensing of quantities such as blood oxygen concentration using a phosphorescent material located at one end of an optical fiber. The phosphorescent material emits a relatively long-lived luminescence when exposed to energy in a predetermined wavelength range. The sensing apparatus includes a light source for generating an incident pulsed energy signal within the predetermined wavelength range and a detector subsystem for selectively detecting the long-lived luminescence from the phosphorescent material. The light source and the detector subsystem are coupled to the other end of the optical fiber along a common optical path. The detector subsystem includes dual channels for detecting a measuring wavelength and a reference wavelength in the long-lived luminescence. The detector subsystem is inhibited during the incident pulsed energy signal to provide low noise operation. The detected signals are integrated and averaged to improve accuracy. A calibration source is provided for calibrating the detection subsystem.

  利用位于光纤一端的磷光材料遥感血氧浓度等量的传感装置。当磷光材料受到预定波长范围内的能量照射时，会发出相对持久的荧光。传感装置包括一个用于在预定波长范围内产生入射脉冲能量信号的光源和一个用于选择性检测磷光材料长寿命发光的检测器子系统。光源和检测器子系统沿着共同的光路耦合到光纤的另一端。检测器子系统包括双通道，用于检测长寿命发光中的测量波长和参考波长。在入射脉冲能量信号期间，检测器子系统处于抑制状态，以实现低噪声运行。对检测到的信号进行整合和平均，以提高精确度。校准源用于校准检测子系统。
• US4092333A
  申请人：——

  公开号：US4092333A

  公开（公告）日：1978-05-30
• US4092334A
  申请人：——

  公开号：US4092334A

  公开（公告）日：1978-05-30
• US4126708A
  申请人：——

  公开号：US4126708A

  公开（公告）日：1978-11-21