2-Benzyloxy-4,5-dimethoxyacetophenon | 65547-69-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Benzyloxy-4,5-dimethoxyacetophenon
• 英文别名: 1-(4,5-Dimethoxy-2-phenylmethoxyphenyl)ethanone
• CAS: 65547-69-5
• 化学式: C₁₇H₁₈O₄
• 分子量: 286.328
• InChiKey: XIONUYSUGQVMCW-UHFFFAOYSA-N

物化性质

• 熔点：
  121 °C(Solv: methanol (67-56-1))
• 沸点：
  437.3±40.0 °C(Predicted)
• 密度：
  1.128±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-苄氧基苯甲醛 、 2-Benzyloxy-4,5-dimethoxyacetophenon 在 potassium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 以81%的产率得到1-(2-(benzyloxy)-4,5-dimethoxyphenyl)-3-(4-(benzyloxy)phenyl)prop-2-en-1-one
  参考文献：
  名称：

  Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos

  摘要：

  Bioassay-guided separation of the extract of the medicinal plant, Puerariae Flos, disclosed the two isoflavones tectorigenin (1) and genistein (2) as the inhibitors for expression of IgE receptor (Fc epsilon RI), the key molecule triggering the allergic reactions, on human mast cells. As a result of analysis of structure-activity relationship of the naturally occurring and synthesized isoflavones, 7-O-methyl glycitein (11) was disclosed as the more potent inhibitor than tectorigenin (1). These isoflavone ingredients suppressed expression of FceRI more potently than the active flavonoids found previously. In addition, tectorigenin (1) was clarified to particularly reduce generation of gamma-chain subunit to suppress expression of FceRI among the three subunits. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.05.038
• 作为产物：
  描述：

  2'-羟基-4',5'-二甲氧基苯乙酮 、 氯化苄 生成 2-Benzyloxy-4,5-dimethoxyacetophenon
  参考文献：
  名称：

  AHLUWALIA V. K.; KUMAR D., INDIAN J. CHEM., 1977, B 15, NO 6, 514-518

  摘要：

  DOI：

文献信息

• Heterocyclic compounds for treating hepatitis C virus
  申请人：Vourloumis Dionisios

  公开号：US20050075375A1

  公开（公告）日：2005-04-07

  The invention is directed to heterocyclic compounds and pharmaceutical compositions of the same for treating Hepatitis C virus.

  这项发明涉及杂环化合物和其制备的药物组合物，用于治疗丙型肝炎病毒。
• [EN] HETEROCYCLIC COMPOUNDS FOR TREATING HEPATITIS C VIRUS<br/>[FR] COMPOSES HETEROCYCLIQUES POUR TRAITER LE VIRUS DE L'HEPATITE C
  申请人：ANADYS PHARMACEUTICALS INC

  公开号：WO2004110351A2

  公开（公告）日：2004-12-23

  The invention is directed to heterocyclic compounds and pharmaceutical compositions of the same for treating Hepatitis C virus.