4-Bromo-cyclohexa-3,5-diene-1,2-diol | 82683-93-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Bromo-cyclohexa-3,5-diene-1,2-diol
• 英文别名: Bromobenzene-3,4-dihydrodiol；4-bromocyclohexa-3,5-diene-1,2-diol
• CAS: 82683-93-0
• 化学式: C₆H₇BrO₂
• 分子量: 191.024
• InChiKey: MWJZOLXUCNEWFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Bromo-cyclohexa-3,5-diene-1,2-diol 在 sodium periodate 、 四丁基溴化铵 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.17h， 生成 4-bromo-1,2-benzoquinone
  参考文献：
  名称：

  Selective synthesis and hydrolysis of dimethyl cis,cis-3-halomuconates

  摘要：

  DOI：

  10.1021/jo00263a053

文献信息

• Probe Compound for Detecting and Isolating Enzymes and Means and Methods Using the Same
  申请人：Golyshin Peter N.

  公开号：US20120231972A1

  公开（公告）日：2012-09-13

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.
• [EN] CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS<br/>[FR] CYANOCYCLOPROPYLCARBOXAMIDES EN TANT QU'INHIBITEURS DE CATHEPSINE
  申请人：ASTRAZENECA AB

  公开号：WO2009001127A1

  公开（公告）日：2008-12-31

  [EN] The present invention relates to compounds of formula (I) for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases, including cathepsins B, K, C, F, H, L, O, S, W and X. Of particular interest are diseases associated with Cathepsin K.
  [FR] L'invention concerne des composés de formule (I) destinés au traitement de maladies associées à l'activité de la cystéine protéase. Les composés selon l'invention sont des inhibiteurs réversibles de cystéines protéases, notamment des cathepsines B, K, C, F, H, L, O, S, W et X. Les maladies associées à la cathepsine K font l'objet d'un intérêt particulier.