1-(4-Methylphenyl)-3-(4-propan-2-ylphenyl)prop-2-en-1-one | 205688-50-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(4-Methylphenyl)-3-(4-propan-2-ylphenyl)prop-2-en-1-one
• CAS: 205688-50-2
• 化学式: C₁₉H₂₀O
• 分子量: 264.367
• InChiKey: MYILNVXHHYPGRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-氨基苯并咪唑 、 1-(4-Methylphenyl)-3-(4-propan-2-ylphenyl)prop-2-en-1-one 在 PAA-g-LDHs 作用下， 以 neat (no solvent) 为溶剂， 生成
  参考文献：
  名称：

  使用高活性和稳定的聚丙烯酸支撑的层状双氢氧化物高效，绿色合成苯并[4,5]咪唑并[1,2- a ]嘧啶

  摘要：

  通过促进高活性和可重复使用的非均相多聚丙烯酸负载的层状双氢氧化物（PAA- g -LDHs）催化剂的合成，已实现了一种简便高效的合成苯并[4,5]咪唑并[1,2- a ]嘧啶的方法1H-苯并[ d ]咪唑-2-胺与α，β-不饱和羰基化合物在无溶剂条件下的一锅反应。PAA- g ^通过接枝反应可逆加成-断裂链转移聚合成功合成了-LDHs催化剂，并通过不同的分析技术对其进行了表征。该反应的显着特征包括方便的一锅法，短反应时间，优异的收率，广泛的底物范围和操作简便性。同样，该催化剂可以重复使用几次连续运行而其催化活性没有任何明显的损失。

  DOI：

  10.1016/j.tet.2017.01.037
• 作为产物：
  描述：

  对甲基苯乙酮 、 4-异丙基苯甲醛 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 生成 1-(4-Methylphenyl)-3-(4-propan-2-ylphenyl)prop-2-en-1-one
  参考文献：
  名称：

  Synthesis of polysubstituted pyridines under combined microwave and ultrasound irradiation: K2CO3-promoted tandem addition/cyclization/hydrogen shift process

  摘要：

  A convenient and efficient K2CO3-promoted tandem reaction of chalcone, malononitrile, and methanol for the synthesis of highly functionalized pyridines has been developed. This multi-component reaction employing the weak nucleophilic agent methanol proceeded smoothly under combined microwave and ultrasound irradiation (CMUI). The reaction mechanism was proposed to consist of a Michael addition. a methoxylation of C N bond, a cyclization to a 1,4-dihydropyridine and an intermolecular hydrogen shift between 1,4-dihydropyridine and initial chalcone. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.103

文献信息

• Lanthanide complexes combined with chiral salen ligands: application in the enantioselective epoxidation reaction of α,β-unsaturated ketones
  作者：Xuexiu Xia、Chengrong Lu、Bei Zhao、Yingming Yao

  DOI：10.1039/c9ra01529a

  日期：——

  1,2-diphenyl-1,2-ethanediamine) were employed in the enantioselective epoxidation of α,β-unsaturated ketones. It was found that the salen–La complex shows the highest efficiency and enantioselectivity. A relatively broad scope of α,β-unsaturated ketones was investigated, and excellent yields (up to 99%) and moderate to good enantioselectivities (37–87%) of the target molecules were achieved.

  容易获得的镧系酰胺 Ln[N(SiMe 3 ) 2 ] 3 (Ln = Nd ( 1 ), Sm ( 2 ), Eu ( 3 ), Yb ( 4 ), La ( 5 )) 与手性 salen 配体 H 2结合La (( S , S )-N , N'-二- ( 3,5-二取代的亚水杨基)-1,2-环己二胺)和H 2 Lb ( ( S , S ) -N , N'-二-(3,5-二取代-水杨基)-1,2-二苯基-1,2-乙二胺)用于α,β-不饱和酮的对映选择性环氧化。结果发现，salen-La 配合物表现出最高的效率和对映选择性。研究了相对广泛的 α,β-不饱和酮，并实现了目标分子的优异产率（高达 99%）和中等至良好的对映选择性（37-87%）。
• Synthesis of polysubstituted pyridines under combined microwave and ultrasound irradiation: K2CO3-promoted tandem addition/cyclization/hydrogen shift process
  作者：Huangdi Feng、Yuan Li、Erik V. Van der Eycken、Yanqing Peng、Gonghua Song

  DOI：10.1016/j.tetlet.2011.12.103

  日期：2012.2

  A convenient and efficient K2CO3-promoted tandem reaction of chalcone, malononitrile, and methanol for the synthesis of highly functionalized pyridines has been developed. This multi-component reaction employing the weak nucleophilic agent methanol proceeded smoothly under combined microwave and ultrasound irradiation (CMUI). The reaction mechanism was proposed to consist of a Michael addition. a methoxylation of C N bond, a cyclization to a 1,4-dihydropyridine and an intermolecular hydrogen shift between 1,4-dihydropyridine and initial chalcone. (C) 2011 Elsevier Ltd. All rights reserved.
• An efficient and green synthesis of benzo[4,5]imidazo[1,2-a]pyrimidines using highly active and stable poly acrylic acid-supported layered double hydroxides
  作者：Mudumala Veeranarayana Reddy、Gangireddy Chandra Sekhar Reddy、Nguyen Thi Kim Lien、Dong Wook Kim、Yeon Tae Jeong

  DOI：10.1016/j.tet.2017.01.037

  日期：2017.3

  facile and efficient method for the synthesis of benzo[4,5]imidazo[1,2-a]pyrimidines has been achieved via highly active and reusable heterogeneous poly acrylic acid-supported layered double hydroxides (PAA-g-LDHs) catalyst promoted one-pot reaction of 1H-benzo[d]imidazol-2-amine, with α,β-unsaturated carbonyl compounds under solvent-free conditions. PAA-g-LDHs catalyst was successfully synthesized via

  通过促进高活性和可重复使用的非均相多聚丙烯酸负载的层状双氢氧化物（PAA- g -LDHs）催化剂的合成，已实现了一种简便高效的合成苯并[4,5]咪唑并[1,2- a ]嘧啶的方法1H-苯并[ d ]咪唑-2-胺与α，β-不饱和羰基化合物在无溶剂条件下的一锅反应。PAA- g ^通过接枝反应可逆加成-断裂链转移聚合成功合成了-LDHs催化剂，并通过不同的分析技术对其进行了表征。该反应的显着特征包括方便的一锅法，短反应时间，优异的收率，广泛的底物范围和操作简便性。同样，该催化剂可以重复使用几次连续运行而其催化活性没有任何明显的损失。