1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione | 61153-76-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione
• 英文别名: licodione；Licodion；1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)propane-1,3-dione
• CAS: 61153-76-2
• 化学式: C₁₅H₁₂O₅
• 分子量: 272.257
• InChiKey: QIEKMEBGIJSGGB-UHFFFAOYSA-N

物化性质

• 沸点：
  569.0±38.0 °C(Predicted)
• 密度：
  1.416±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2914501900

反应信息

• 作为反应物：
  描述：

  1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione 在 盐酸 、 溶剂黄146 作用下， 反应 1.5h， 生成 7,4’-二羟基黄酮
  参考文献：
  名称：

  Gothelf, Kurt V.; Torssell, Kurt B. G., Acta Chemica Scandinavica, 1994, vol. 48, # 1, p. 61 - 67

  摘要：

  DOI：
• 作为产物：
  描述：

  4-碘苯-1,3-二醇 在 Ra-Ni tris-(dibenzylideneacetone)dipalladium(0) 、 乙醇 、 三苯胂 、 氢气 作用下， 以 1,4-二氧六环 为溶剂， 50.0 ℃ 、101.33 kPa 条件下， 反应 48.0h， 生成 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione
  参考文献：
  名称：

  Gothelf, Kurt V.; Torssell, Kurt B. G., Acta Chemica Scandinavica, 1994, vol. 48, # 1, p. 61 - 67

  摘要：

  DOI：

文献信息

• Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures
  作者：Masuo Ichimura、Tetsuo Furuno、Takeyoshi Takahashi、Richard A. Dixon、Shin-Ichi Ayabe

  DOI：10.1016/s0031-9422(96)00670-x

  日期：1997.3

  this study, cultured alfalfa cells were shown to exhibit rapid and transient increases in the extractable activities of both CHMT and LMT after treatment with yeast extract (YE). Treatment of solution-cultured alfalfa seedlings with YE also resulted in a similar induction of both CHMT and LMT activities in the roots, but no activity was detected in the shoots. These activities were attributed to a single

  S-腺苷-L-甲硫氨酸（SAM）：异甘草素（2',4,4'-三羟基查尔酮）苜蓿（Medicago sativa）的2'-O-甲基转移酶（CHMT）催化4,4'-二羟基-2的形成'-甲氧基查尔酮，它是根瘤菌根瘤基因最有效的诱导剂，苜蓿的共生体形成固氮根瘤。SAM：甘草二酮 2'-O-甲基转移酶 (LMT) 参与培养的甘草 (Glycyrrhiza echinata) 细胞中逆查尔酮的生物合成，并已被证明作为细胞的防御反应被诱导。因为 licodione 存在于互变异构 2',4,4',β-四羟基查尔酮（主要）和 1-（2,4-二羟基苯基）-3-（4-羟基苯基）-1,3-丙二酮（次要）的平衡混合物中，两种酶的表观作用方式非常相似。在这项研究中，在用酵母提取物 (YE) 处理后，培养的苜蓿细胞显示出 CHMT 和 LMT 的可提取活性的快速和瞬时增加。用 YE 处理溶液培养的苜蓿幼苗也导致根中 CHMT
• GENE ENCODING FLAVONE SYNTHASE
  申请人：SUNTORY LIMITED

  公开号：EP1067189A1

  公开（公告）日：2001-01-10

  DNA obtained, for example, from snapdragon or torenia, encoding an enzyme that can convert flavanones directly to flavones, and its uses; the DNA and amino acid sequences for enzymes encoded thereby are listed as SEQ.ID. No. 1 & 2 and 3 & 4, for example. Introduction of the genes into plants can, for example, alter the flower colors of the plants.

  例如，从龙须菜或香椿中获得的 DNA，编码可将黄酮直接转化为黄酮的酶及其用途；其编码的酶的 DNA 和氨基酸序列列于 SEQ.ID.1和2以及3和4。将这些基因导入植物可改变植物的花色等。
• Genes coding for flavone synthases
  申请人：SUNTORY LIMITED

  公开号：EP1726653A2

  公开（公告）日：2006-11-29

  DNA obtained, for example, from snapdragon or torenia, encoding an enzyme that can convert flavanones directly to flavones, and its uses; the DNA and amino acid sequences for enzymes encoded thereby are listed as SEQ.ID. No. 1 & 2 and 3 & 4, for example. Introduction of the genes into plants can, for example, alter the flower colors of the plants.

  例如，从龙须菜或香椿中获得的 DNA，编码可将黄酮直接转化为黄酮的酶及其用途；其编码的酶的 DNA 和氨基酸序列列于 SEQ.ID.1和2以及3和4。将这些基因导入植物可改变植物的花色等。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• DNAs coding for flavone synthases, methods of using flavone synthase DNAs, and plants, flowers, and vectors containing flavone synthase DNAs
  申请人：Mizutani Masako

  公开号：US20060248609A1

  公开（公告）日：2006-11-02

  DNA obtained, for example, from snapdragon or torenia, encoding an enzyme that can convert flavanones directly to flavones, and its uses; the DNA and amino acid sequences for enzymes encoded thereby are listed as SEQ. ID. No. 1 & 2 and 3 & 4, for example. Introduction of the genes into plants can, for example, alter the flower colors of the plants.

  例如，从龙须菜或鸢尾属植物中获得的 DNA 黄酮 编码可将黄酮直接转化为黄酮的酶及其用途；其编码的酶的 DNA 和氨基酸序列列为 SEQ.ID.1和2以及3和4。将这些基因导入植物可改变植物的花色等。